GRB10 protein (Macaca mulatta) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

GRB10

Uncharacterized protein. (631 aa)

Predicted Functional Partners:

IGF1R

0.990

MTOR

0.910

NEDD4

0.871

INSR

0.870

CPA4

0.726

GIGYF2

0.725

PIK3R1

0.720

IGF1

0.702

EGFR

0.677

GIGYF1

0.666

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPA4	GRB10	ENSMMUP00000046428	ENSMMUP00000026288	Carboxypeptidase A4.	Uncharacterized protein.	0.726
EGFR	GRB10	ENSMMUP00000046120	ENSMMUP00000026288	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Uncharacterized protein.	0.677
EGFR	IGF1	ENSMMUP00000046120	ENSMMUP00000002988	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Insulin like growth factor 1.	0.966
EGFR	IGF1R	ENSMMUP00000046120	ENSMMUP00000016141	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Tyrosine-protein kinase receptor.	0.982
EGFR	INSR	ENSMMUP00000046120	ENSMMUP00000045695	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Insulin receptor subunit alpha; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lea [...]	0.453
EGFR	NEDD4	ENSMMUP00000046120	ENSMMUP00000073029	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	NEDD4 E3 ubiquitin protein ligase.	0.894
EGFR	PIK3R1	ENSMMUP00000046120	ENSMMUP00000015140	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Phosphoinositide-3-kinase regulatory subunit 1.	0.990
GIGYF1	GRB10	ENSMMUP00000035437	ENSMMUP00000026288	GRB10 interacting GYF protein 1.	Uncharacterized protein.	0.666
GIGYF2	GRB10	ENSMMUP00000016014	ENSMMUP00000026288	PERQ amino acid-rich with GYF domain-containing protein 2 isoform b.	Uncharacterized protein.	0.725
GRB10	CPA4	ENSMMUP00000026288	ENSMMUP00000046428	Uncharacterized protein.	Carboxypeptidase A4.	0.726
GRB10	EGFR	ENSMMUP00000026288	ENSMMUP00000046120	Uncharacterized protein.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.677
GRB10	GIGYF1	ENSMMUP00000026288	ENSMMUP00000035437	Uncharacterized protein.	GRB10 interacting GYF protein 1.	0.666
GRB10	GIGYF2	ENSMMUP00000026288	ENSMMUP00000016014	Uncharacterized protein.	PERQ amino acid-rich with GYF domain-containing protein 2 isoform b.	0.725
GRB10	IGF1	ENSMMUP00000026288	ENSMMUP00000002988	Uncharacterized protein.	Insulin like growth factor 1.	0.702
GRB10	IGF1R	ENSMMUP00000026288	ENSMMUP00000016141	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.990
GRB10	INSR	ENSMMUP00000026288	ENSMMUP00000045695	Uncharacterized protein.	Insulin receptor subunit alpha; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lea [...]	0.870
GRB10	MTOR	ENSMMUP00000026288	ENSMMUP00000073444	Uncharacterized protein.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.910
GRB10	NEDD4	ENSMMUP00000026288	ENSMMUP00000073029	Uncharacterized protein.	NEDD4 E3 ubiquitin protein ligase.	0.871
GRB10	PIK3R1	ENSMMUP00000026288	ENSMMUP00000015140	Uncharacterized protein.	Phosphoinositide-3-kinase regulatory subunit 1.	0.720
IGF1	EGFR	ENSMMUP00000002988	ENSMMUP00000046120	Insulin like growth factor 1.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.966