STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TFPI2Tissue factor pathway inhibitor. (289 aa)    
Predicted Functional Partners:
THBD
Uncharacterized protein.
   
 
 0.916
F7
Coagulation factor VII.
    
 0.734
SERPIND1
Serpin family D member 1; Belongs to the serpin family.
   
 
 0.729
VWF
Uncharacterized protein.
   
  
 0.714
PLAT
Plasminogen activator; Belongs to the peptidase S1 family.
   
 0.701
F3
Tissue factor isoform 1.
   
 
 0.667
SERPINA5
SERPIN domain-containing protein; Belongs to the serpin family.
   
 
 0.667
F2
Coagulation factor II, thrombin; Belongs to the peptidase S1 family.
   
 0.648
SERPINC1
Antithrombin III; Belongs to the serpin family.
   
 
 0.628
PLG
Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...]
    
 0.615
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.