ZAP70 protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD247	CD3D	ENSMMUP00000059589	ENSMMUP00000023161	CD247 molecule.	Ig_4 domain-containing protein.	0.999
CD247	CD3E	ENSMMUP00000059589	ENSMMUP00000062612	CD247 molecule.	CD3e molecule.	0.998
CD247	CD4	ENSMMUP00000059589	ENSMMUP00000069370	CD247 molecule.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.757
CD247	LCK	ENSMMUP00000059589	ENSMMUP00000044699	CD247 molecule.	Tyrosine-protein kinase.	0.965
CD247	LCP2	ENSMMUP00000059589	ENSMMUP00000057834	CD247 molecule.	Lymphocyte cytosolic protein 2.	0.823
CD247	PTPN11	ENSMMUP00000059589	ENSMMUP00000050217	CD247 molecule.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.975
CD247	SHC1	ENSMMUP00000059589	ENSMMUP00000008658	CD247 molecule.	SHC-transforming protein 1 isoform 3.	0.740
CD247	VAV1	ENSMMUP00000059589	ENSMMUP00000058900	CD247 molecule.	Vav guanine nucleotide exchange factor 1.	0.585
CD247	ZAP70	ENSMMUP00000059589	ENSMMUP00000028374	CD247 molecule.	Tyrosine-protein kinase.	0.999
CD3D	CD247	ENSMMUP00000023161	ENSMMUP00000059589	Ig_4 domain-containing protein.	CD247 molecule.	0.999
CD3D	CD3E	ENSMMUP00000023161	ENSMMUP00000062612	Ig_4 domain-containing protein.	CD3e molecule.	0.999
CD3D	CD4	ENSMMUP00000023161	ENSMMUP00000069370	Ig_4 domain-containing protein.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.706
CD3D	LCK	ENSMMUP00000023161	ENSMMUP00000044699	Ig_4 domain-containing protein.	Tyrosine-protein kinase.	0.884
CD3D	LCP2	ENSMMUP00000023161	ENSMMUP00000057834	Ig_4 domain-containing protein.	Lymphocyte cytosolic protein 2.	0.658
CD3D	SHC1	ENSMMUP00000023161	ENSMMUP00000008658	Ig_4 domain-containing protein.	SHC-transforming protein 1 isoform 3.	0.530
CD3D	ZAP70	ENSMMUP00000023161	ENSMMUP00000028374	Ig_4 domain-containing protein.	Tyrosine-protein kinase.	0.995
CD3E	CD247	ENSMMUP00000062612	ENSMMUP00000059589	CD3e molecule.	CD247 molecule.	0.998
CD3E	CD3D	ENSMMUP00000062612	ENSMMUP00000023161	CD3e molecule.	Ig_4 domain-containing protein.	0.999
CD3E	CD4	ENSMMUP00000062612	ENSMMUP00000069370	CD3e molecule.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.895
CD3E	LCK	ENSMMUP00000062612	ENSMMUP00000044699	CD3e molecule.	Tyrosine-protein kinase.	0.905