TLR3 protein (Macaca mulatta) - STRING interaction network

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gene neighborhood

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textmining

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Score

TLR3

Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)

Predicted Functional Partners:

TICAM1

0.989

TRAF6

0.986

UNC93B1

0.981

RIPK1

0.971

MYD88

0.970

TAB2

0.962

TAB1

0.944

MAP3K7

0.943

TBK1

0.941

IRF3

0.938

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IRF3	MYD88	ENSMMUP00000029942	ENSMMUP00000001339	Interferon regulatory factor 3.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.908
IRF3	RIPK1	ENSMMUP00000029942	ENSMMUP00000011125	Interferon regulatory factor 3.	Receptor interacting serine/threonine kinase 1.	0.517
IRF3	TAB1	ENSMMUP00000029942	ENSMMUP00000015873	Interferon regulatory factor 3.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha.	0.428
IRF3	TAB2	ENSMMUP00000029942	ENSMMUP00000019658	Interferon regulatory factor 3.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2.	0.448
IRF3	TBK1	ENSMMUP00000029942	ENSMMUP00000010063	Interferon regulatory factor 3.	Serine/threonine-protein kinase TBK1.	0.997
IRF3	TICAM1	ENSMMUP00000029942	ENSMMUP00000031953	Interferon regulatory factor 3.	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.	0.954
IRF3	TLR3	ENSMMUP00000029942	ENSMMUP00000028658	Interferon regulatory factor 3.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.938
IRF3	TRAF6	ENSMMUP00000029942	ENSMMUP00000024012	Interferon regulatory factor 3.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.856
IRF3	UNC93B1	ENSMMUP00000029942	ENSMMUP00000068702	Interferon regulatory factor 3.	Unc-93 homolog B1, TLR signaling regulator.	0.472
MAP3K7	MYD88	ENSMMUP00000033340	ENSMMUP00000001339	Mitogen-activated protein kinase kinase kinase 7.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.997
MAP3K7	RIPK1	ENSMMUP00000033340	ENSMMUP00000011125	Mitogen-activated protein kinase kinase kinase 7.	Receptor interacting serine/threonine kinase 1.	0.981
MAP3K7	TAB1	ENSMMUP00000033340	ENSMMUP00000015873	Mitogen-activated protein kinase kinase kinase 7.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha.	0.999
MAP3K7	TAB2	ENSMMUP00000033340	ENSMMUP00000019658	Mitogen-activated protein kinase kinase kinase 7.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2.	0.999
MAP3K7	TICAM1	ENSMMUP00000033340	ENSMMUP00000031953	Mitogen-activated protein kinase kinase kinase 7.	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.	0.742
MAP3K7	TLR3	ENSMMUP00000033340	ENSMMUP00000028658	Mitogen-activated protein kinase kinase kinase 7.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.943
MAP3K7	TRAF6	ENSMMUP00000033340	ENSMMUP00000024012	Mitogen-activated protein kinase kinase kinase 7.	TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]	0.999
MYD88	IRF3	ENSMMUP00000001339	ENSMMUP00000029942	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	Interferon regulatory factor 3.	0.908
MYD88	MAP3K7	ENSMMUP00000001339	ENSMMUP00000033340	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	Mitogen-activated protein kinase kinase kinase 7.	0.997
MYD88	RIPK1	ENSMMUP00000001339	ENSMMUP00000011125	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	Receptor interacting serine/threonine kinase 1.	0.693
MYD88	TAB1	ENSMMUP00000001339	ENSMMUP00000015873	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha.	0.969