IRS2 protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GRB2	IGF1R	ENSMMUP00000045339	ENSMMUP00000016141	Growth factor receptor-bound protein 2 isoform 1.	Tyrosine-protein kinase receptor.	0.974
GRB2	INS	ENSMMUP00000045339	ENSMMUP00000037777	Growth factor receptor-bound protein 2 isoform 1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.741
GRB2	INSR	ENSMMUP00000045339	ENSMMUP00000045695	Growth factor receptor-bound protein 2 isoform 1.	Insulin receptor subunit alpha; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lea [...]	0.980
GRB2	IRS1	ENSMMUP00000045339	ENSMMUP00000045227	Growth factor receptor-bound protein 2 isoform 1.	Insulin receptor substrate 1.	0.998
GRB2	IRS2	ENSMMUP00000045339	ENSMMUP00000028694	Growth factor receptor-bound protein 2 isoform 1.	Insulin receptor substrate 2.	0.988
GRB2	JAK2	ENSMMUP00000045339	ENSMMUP00000019119	Growth factor receptor-bound protein 2 isoform 1.	Tyrosine-protein kinase.	0.888
GRB2	PIK3CA	ENSMMUP00000045339	ENSMMUP00000006866	Growth factor receptor-bound protein 2 isoform 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.937
GRB2	PIK3CB	ENSMMUP00000045339	ENSMMUP00000011365	Growth factor receptor-bound protein 2 isoform 1.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.863
GRB2	PIK3R1	ENSMMUP00000045339	ENSMMUP00000015140	Growth factor receptor-bound protein 2 isoform 1.	Phosphoinositide-3-kinase regulatory subunit 1.	0.972
GRB2	SOCS1	ENSMMUP00000045339	ENSMMUP00000014368	Growth factor receptor-bound protein 2 isoform 1.	Suppressor of cytokine signaling 1.	0.410
IGF1R	GRB2	ENSMMUP00000016141	ENSMMUP00000045339	Tyrosine-protein kinase receptor.	Growth factor receptor-bound protein 2 isoform 1.	0.974
IGF1R	INS	ENSMMUP00000016141	ENSMMUP00000037777	Tyrosine-protein kinase receptor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.996
IGF1R	INSR	ENSMMUP00000016141	ENSMMUP00000045695	Tyrosine-protein kinase receptor.	Insulin receptor subunit alpha; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lea [...]	0.994
IGF1R	IRS1	ENSMMUP00000016141	ENSMMUP00000045227	Tyrosine-protein kinase receptor.	Insulin receptor substrate 1.	0.997
IGF1R	IRS2	ENSMMUP00000016141	ENSMMUP00000028694	Tyrosine-protein kinase receptor.	Insulin receptor substrate 2.	0.988
IGF1R	JAK2	ENSMMUP00000016141	ENSMMUP00000019119	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase.	0.931
IGF1R	PIK3CA	ENSMMUP00000016141	ENSMMUP00000006866	Tyrosine-protein kinase receptor.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.984
IGF1R	PIK3CB	ENSMMUP00000016141	ENSMMUP00000011365	Tyrosine-protein kinase receptor.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.966
IGF1R	PIK3R1	ENSMMUP00000016141	ENSMMUP00000015140	Tyrosine-protein kinase receptor.	Phosphoinositide-3-kinase regulatory subunit 1.	0.984
IGF1R	SOCS1	ENSMMUP00000016141	ENSMMUP00000014368	Tyrosine-protein kinase receptor.	Suppressor of cytokine signaling 1.	0.670