MAPKAPK5 protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HSPB1	HSPB6	ENSMMUP00000075911	ENSMMUP00000003204	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family.	Heat shock protein beta-6; Belongs to the small heat shock protein (HSP20) family.	0.486
HSPB1	MAPK11	ENSMMUP00000075911	ENSMMUP00000018541	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family.	Mitogen-activated protein kinase.	0.555
HSPB1	MAPK13	ENSMMUP00000075911	ENSMMUP00000045645	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family.	Mitogen-activated protein kinase.	0.537
HSPB1	MAPK14	ENSMMUP00000075911	ENSMMUP00000011075	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family.	Mitogen-activated protein kinase.	0.655
HSPB1	MAPK4	ENSMMUP00000075911	ENSMMUP00000065817	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family.	Mitogen-activated protein kinase 4.	0.570
HSPB1	MAPK6	ENSMMUP00000075911	ENSMMUP00000070359	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family.	Mitogen-activated protein kinase 6.	0.627
HSPB1	MAPKAPK5	ENSMMUP00000075911	ENSMMUP00000073413	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family.	MAP kinase-activated protein kinase 5 isoform 1.	0.996
HSPB1	TP53	ENSMMUP00000075911	ENSMMUP00000011334	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.837
HSPB6	HSPB1	ENSMMUP00000003204	ENSMMUP00000075911	Heat shock protein beta-6; Belongs to the small heat shock protein (HSP20) family.	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family.	0.486
HSPB6	MAPK4	ENSMMUP00000003204	ENSMMUP00000065817	Heat shock protein beta-6; Belongs to the small heat shock protein (HSP20) family.	Mitogen-activated protein kinase 4.	0.433
HSPB6	MAPK6	ENSMMUP00000003204	ENSMMUP00000070359	Heat shock protein beta-6; Belongs to the small heat shock protein (HSP20) family.	Mitogen-activated protein kinase 6.	0.431
HSPB6	MAPKAPK5	ENSMMUP00000003204	ENSMMUP00000073413	Heat shock protein beta-6; Belongs to the small heat shock protein (HSP20) family.	MAP kinase-activated protein kinase 5 isoform 1.	0.815
HSPB6	TP53	ENSMMUP00000003204	ENSMMUP00000011334	Heat shock protein beta-6; Belongs to the small heat shock protein (HSP20) family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.623
MAPK11	HSPB1	ENSMMUP00000018541	ENSMMUP00000075911	Mitogen-activated protein kinase.	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family.	0.555
MAPK11	MAPK13	ENSMMUP00000018541	ENSMMUP00000045645	Mitogen-activated protein kinase.	Mitogen-activated protein kinase.	0.975
MAPK11	MAPK14	ENSMMUP00000018541	ENSMMUP00000011075	Mitogen-activated protein kinase.	Mitogen-activated protein kinase.	0.977
MAPK11	MAPKAPK5	ENSMMUP00000018541	ENSMMUP00000073413	Mitogen-activated protein kinase.	MAP kinase-activated protein kinase 5 isoform 1.	0.982
MAPK11	RPS6KA3	ENSMMUP00000018541	ENSMMUP00000052548	Mitogen-activated protein kinase.	Ribosomal protein S6 kinase.	0.435
MAPK11	TP53	ENSMMUP00000018541	ENSMMUP00000011334	Mitogen-activated protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.985
MAPK13	HSPB1	ENSMMUP00000045645	ENSMMUP00000075911	Mitogen-activated protein kinase.	Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family.	0.537