OPRM1 protein (Macaca mulatta) - STRING interaction network

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OPRM1

Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] (400 aa)

Predicted Functional Partners:

PENK

0.962

PDYN

0.962

ARRB1

0.931

ARRB2

0.930

OPRK1

0.928

OPRL1

0.924

LOC694289

0.921

GRK3

0.921

GNB5

0.919

GNB4

0.918

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB1	ARRB2	ENSMMUP00000077529	ENSMMUP00000067243	Arrestin beta 1.	Arrestin beta 2.	0.960
ARRB1	GRK3	ENSMMUP00000077529	ENSMMUP00000064465	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.906
ARRB1	OPRM1	ENSMMUP00000077529	ENSMMUP00000043883	Arrestin beta 1.	Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...]	0.931
ARRB2	ARRB1	ENSMMUP00000067243	ENSMMUP00000077529	Arrestin beta 2.	Arrestin beta 1.	0.960
ARRB2	GRK3	ENSMMUP00000067243	ENSMMUP00000064465	Arrestin beta 2.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.924
ARRB2	OPRK1	ENSMMUP00000067243	ENSMMUP00000069541	Arrestin beta 2.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.452
ARRB2	OPRM1	ENSMMUP00000067243	ENSMMUP00000043883	Arrestin beta 2.	Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...]	0.930
GNB4	GNB5	ENSMMUP00000005459	ENSMMUP00000022869	Guanine nucleotide-binding protein subunit beta-4.	G protein subunit beta 5.	0.728
GNB4	GRK3	ENSMMUP00000005459	ENSMMUP00000064465	Guanine nucleotide-binding protein subunit beta-4.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.673
GNB4	LOC694289	ENSMMUP00000005459	ENSMMUP00000013436	Guanine nucleotide-binding protein subunit beta-4.	Uncharacterized protein.	0.976
GNB4	OPRK1	ENSMMUP00000005459	ENSMMUP00000069541	Guanine nucleotide-binding protein subunit beta-4.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.590
GNB4	OPRL1	ENSMMUP00000005459	ENSMMUP00000044226	Guanine nucleotide-binding protein subunit beta-4.	Nociceptin receptor; Belongs to the G-protein coupled receptor 1 family.	0.574
GNB4	OPRM1	ENSMMUP00000005459	ENSMMUP00000043883	Guanine nucleotide-binding protein subunit beta-4.	Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...]	0.918
GNB5	GNB4	ENSMMUP00000022869	ENSMMUP00000005459	G protein subunit beta 5.	Guanine nucleotide-binding protein subunit beta-4.	0.728
GNB5	GRK3	ENSMMUP00000022869	ENSMMUP00000064465	G protein subunit beta 5.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.588
GNB5	LOC694289	ENSMMUP00000022869	ENSMMUP00000013436	G protein subunit beta 5.	Uncharacterized protein.	0.974
GNB5	OPRL1	ENSMMUP00000022869	ENSMMUP00000044226	G protein subunit beta 5.	Nociceptin receptor; Belongs to the G-protein coupled receptor 1 family.	0.474
GNB5	OPRM1	ENSMMUP00000022869	ENSMMUP00000043883	G protein subunit beta 5.	Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...]	0.919
GRK3	ARRB1	ENSMMUP00000064465	ENSMMUP00000077529	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Arrestin beta 1.	0.906
GRK3	ARRB2	ENSMMUP00000064465	ENSMMUP00000067243	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Arrestin beta 2.	0.924

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