HOXD8 protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HOXD8

Homeobox D8. (292 aa)

Predicted Functional Partners:

COL2A1

0.741

MKX

0.691

CUX2

0.660

LIM2

0.651

MEIS2

0.640

HOXC9

0.562

PBX1

0.556

PBX2

0.556

PBX3

0.556

PBX4

0.556

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COL2A1	HOXD8	ENSMMUP00000015024	ENSMMUP00000030941	Collagen type II alpha 1 chain.	Homeobox D8.	0.741
CUX2	HOXC9	ENSMMUP00000066240	ENSMMUP00000041366	Homeobox protein cut-like.	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	0.651
CUX2	HOXD8	ENSMMUP00000066240	ENSMMUP00000030941	Homeobox protein cut-like.	Homeobox D8.	0.660
CUX2	LIM2	ENSMMUP00000066240	ENSMMUP00000067738	Homeobox protein cut-like.	Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family.	0.655
CUX2	MEIS2	ENSMMUP00000066240	ENSMMUP00000050063	Homeobox protein cut-like.	Meis homeobox 2.	0.502
CUX2	MKX	ENSMMUP00000066240	ENSMMUP00000027187	Homeobox protein cut-like.	Mohawk homeobox.	0.652
HOXC9	CUX2	ENSMMUP00000041366	ENSMMUP00000066240	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Homeobox protein cut-like.	0.651
HOXC9	HOXD8	ENSMMUP00000041366	ENSMMUP00000030941	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Homeobox D8.	0.562
HOXC9	LIM2	ENSMMUP00000041366	ENSMMUP00000067738	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family.	0.651
HOXC9	MEIS2	ENSMMUP00000041366	ENSMMUP00000050063	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Meis homeobox 2.	0.555
HOXC9	MKX	ENSMMUP00000041366	ENSMMUP00000027187	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Mohawk homeobox.	0.685
HOXC9	PBX1	ENSMMUP00000041366	ENSMMUP00000014901	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Pre-B-cell leukemia transcription factor 1 isoform 1.	0.770
HOXC9	PBX2	ENSMMUP00000041366	ENSMMUP00000018094	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Pre-B-cell leukemia transcription factor 2.	0.680
HOXC9	PBX3	ENSMMUP00000041366	ENSMMUP00000018097	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Pre-B-cell leukemia transcription factor 3 isoform 1.	0.680
HOXC9	PBX4	ENSMMUP00000041366	ENSMMUP00000054807	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	PBX homeobox 4.	0.680
HOXD8	COL2A1	ENSMMUP00000030941	ENSMMUP00000015024	Homeobox D8.	Collagen type II alpha 1 chain.	0.741
HOXD8	CUX2	ENSMMUP00000030941	ENSMMUP00000066240	Homeobox D8.	Homeobox protein cut-like.	0.660
HOXD8	HOXC9	ENSMMUP00000030941	ENSMMUP00000041366	Homeobox D8.	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	0.562
HOXD8	LIM2	ENSMMUP00000030941	ENSMMUP00000067738	Homeobox D8.	Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family.	0.651
HOXD8	MEIS2	ENSMMUP00000030941	ENSMMUP00000050063	Homeobox D8.	Meis homeobox 2.	0.640