| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APPBP2 | PPM1D | ENSMMUP00000021765 | ENSMMUP00000023722 | Amyloid beta precursor protein binding protein 2. | Protein phosphatase, Mg2+/Mn2+ dependent 1D. | 0.608 |
| ASXL1 | PPM1D | ENSMMUP00000053692 | ENSMMUP00000023722 | ASXL transcriptional regulator 1. | Protein phosphatase, Mg2+/Mn2+ dependent 1D. | 0.638 |
| ASXL1 | RUNX1 | ENSMMUP00000053692 | ENSMMUP00000075631 | ASXL transcriptional regulator 1. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.790 |
| ASXL1 | TP53 | ENSMMUP00000053692 | ENSMMUP00000011334 | ASXL transcriptional regulator 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.579 |
| C12orf43 | PPM1D | ENSMMUP00000051700 | ENSMMUP00000023722 | Chromosome 12 open reading frame 43. | Protein phosphatase, Mg2+/Mn2+ dependent 1D. | 0.627 |
| CBFB | ENSMMUP00000077416 | ENSMMUP00000070667 | ENSMMUP00000077416 | Core-binding factor subunit beta isoform 1. | Uncharacterized protein. | 0.903 |
| CBFB | PPM1D | ENSMMUP00000070667 | ENSMMUP00000023722 | Core-binding factor subunit beta isoform 1. | Protein phosphatase, Mg2+/Mn2+ dependent 1D. | 0.710 |
| CBFB | RUNX1 | ENSMMUP00000070667 | ENSMMUP00000075631 | Core-binding factor subunit beta isoform 1. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.966 |
| CBFB | RUNX2 | ENSMMUP00000070667 | ENSMMUP00000070378 | Core-binding factor subunit beta isoform 1. | RUNX family transcription factor 2. | 0.916 |
| CHEK2 | MDM2 | ENSMMUP00000037133 | ENSMMUP00000018645 | Checkpoint kinase 2. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.966 |
| CHEK2 | PPM1D | ENSMMUP00000037133 | ENSMMUP00000023722 | Checkpoint kinase 2. | Protein phosphatase, Mg2+/Mn2+ dependent 1D. | 0.747 |
| CHEK2 | TP53 | ENSMMUP00000037133 | ENSMMUP00000011334 | Checkpoint kinase 2. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.999 |
| ENSMMUP00000077416 | CBFB | ENSMMUP00000077416 | ENSMMUP00000070667 | Uncharacterized protein. | Core-binding factor subunit beta isoform 1. | 0.903 |
| ENSMMUP00000077416 | PPM1D | ENSMMUP00000077416 | ENSMMUP00000023722 | Uncharacterized protein. | Protein phosphatase, Mg2+/Mn2+ dependent 1D. | 0.664 |
| ENSMMUP00000077416 | RUNX1 | ENSMMUP00000077416 | ENSMMUP00000075631 | Uncharacterized protein. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.953 |
| ENSMMUP00000077416 | RUNX2 | ENSMMUP00000077416 | ENSMMUP00000070378 | Uncharacterized protein. | RUNX family transcription factor 2. | 0.916 |
| MDM2 | CHEK2 | ENSMMUP00000018645 | ENSMMUP00000037133 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Checkpoint kinase 2. | 0.966 |
| MDM2 | PPM1D | ENSMMUP00000018645 | ENSMMUP00000023722 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Protein phosphatase, Mg2+/Mn2+ dependent 1D. | 0.688 |
| MDM2 | RUNX1 | ENSMMUP00000018645 | ENSMMUP00000075631 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.724 |
| MDM2 | RUNX2 | ENSMMUP00000018645 | ENSMMUP00000070378 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | RUNX family transcription factor 2. | 0.686 |
