GAB1 protein (Macaca mulatta) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

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protein homology

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[Homology]

Score

GAB1

PH domain-containing protein. (790 aa)

Predicted Functional Partners:

GRB2

0.998

PTPN11

0.996

MET

0.981

MST1R

0.975

EGFR

0.926

PTPN6

0.920

PIK3R1

0.890

FRS2

0.880

SOS1

0.864

SHC1

0.852

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	GAB1	ENSMMUP00000046120	ENSMMUP00000034752	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	PH domain-containing protein.	0.926
EGFR	GRB2	ENSMMUP00000046120	ENSMMUP00000045339	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Growth factor receptor-bound protein 2 isoform 1.	0.999
EGFR	MET	ENSMMUP00000046120	ENSMMUP00000008920	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Uncharacterized protein.	0.917
EGFR	MST1R	ENSMMUP00000046120	ENSMMUP00000004467	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Macrophage stimulating 1 receptor.	0.819
EGFR	PIK3R1	ENSMMUP00000046120	ENSMMUP00000015140	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Phosphoinositide-3-kinase regulatory subunit 1.	0.990
EGFR	PTPN11	ENSMMUP00000046120	ENSMMUP00000050217	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.998
EGFR	PTPN6	ENSMMUP00000046120	ENSMMUP00000013344	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.650
EGFR	SHC1	ENSMMUP00000046120	ENSMMUP00000008658	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	SHC-transforming protein 1 isoform 3.	0.998
EGFR	SOS1	ENSMMUP00000046120	ENSMMUP00000066881	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.997
FRS2	GAB1	ENSMMUP00000014180	ENSMMUP00000034752	Fibroblast growth factor receptor substrate 2.	PH domain-containing protein.	0.880
FRS2	GRB2	ENSMMUP00000014180	ENSMMUP00000045339	Fibroblast growth factor receptor substrate 2.	Growth factor receptor-bound protein 2 isoform 1.	0.998
FRS2	PIK3R1	ENSMMUP00000014180	ENSMMUP00000015140	Fibroblast growth factor receptor substrate 2.	Phosphoinositide-3-kinase regulatory subunit 1.	0.434
FRS2	PTPN11	ENSMMUP00000014180	ENSMMUP00000050217	Fibroblast growth factor receptor substrate 2.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.948
FRS2	PTPN6	ENSMMUP00000014180	ENSMMUP00000013344	Fibroblast growth factor receptor substrate 2.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.661
FRS2	SHC1	ENSMMUP00000014180	ENSMMUP00000008658	Fibroblast growth factor receptor substrate 2.	SHC-transforming protein 1 isoform 3.	0.538
FRS2	SOS1	ENSMMUP00000014180	ENSMMUP00000066881	Fibroblast growth factor receptor substrate 2.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.897
GAB1	EGFR	ENSMMUP00000034752	ENSMMUP00000046120	PH domain-containing protein.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.926
GAB1	FRS2	ENSMMUP00000034752	ENSMMUP00000014180	PH domain-containing protein.	Fibroblast growth factor receptor substrate 2.	0.880
GAB1	GRB2	ENSMMUP00000034752	ENSMMUP00000045339	PH domain-containing protein.	Growth factor receptor-bound protein 2 isoform 1.	0.998
GAB1	MET	ENSMMUP00000034752	ENSMMUP00000008920	PH domain-containing protein.	Uncharacterized protein.	0.981