STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OPTNOptineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (593 aa)    
Predicted Functional Partners:
TBK1
Serine/threonine-protein kinase TBK1.
   
 0.996
GABARAPL2
Gamma-aminobutyric acid receptor-associated protein-like 2.
   
 0.970
GABARAP
Gamma-aminobutyric acid receptor-associated protein.
   
 0.952
LOC702827
Uncharacterized protein.
   
 0.945
GABARAPL1
Uncharacterized protein.
   
 0.943
TANK
TRAF family member-associated NF-kappa-B activator isoform a.
   
 0.926
UBB
Uncharacterized protein.
   
 0.907
UBE2V1
TMEM189_B_dmain domain-containing protein.
   
 
 0.897
RAB8A
Ras-related protein Rab-8A.
   
 0.886
RB1CC1
RB1-inducible coiled-coil protein 1 isoform 1.
    
 
 0.862
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.