CHEK1 protein (Macaca mulatta) - STRING interaction network

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gene neighborhood

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Score

CHEK1

STT3 oligosaccharyltransferase complex catalytic subunit A. (768 aa)

Predicted Functional Partners:

ATR

0.998

CDC25C

0.993

CDC25A

0.991

TP53

0.990

CHEK2

0.990

CDC25B

0.986

ATM

0.985

WEE1

0.978

CLSPN

0.974

WEE2

0.971

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	ENSMMUP00000005561	ENSMMUP00000010409	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.999
ATM	CDC25A	ENSMMUP00000005561	ENSMMUP00000027572	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	M-phase inducer phosphatase 1 isoform a.	0.631
ATM	CDC25C	ENSMMUP00000005561	ENSMMUP00000011824	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cell division cycle 25C.	0.529
ATM	CHEK1	ENSMMUP00000005561	ENSMMUP00000036602	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	STT3 oligosaccharyltransferase complex catalytic subunit A.	0.985
ATM	CHEK2	ENSMMUP00000005561	ENSMMUP00000037133	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Checkpoint kinase 2.	0.997
ATM	CLSPN	ENSMMUP00000005561	ENSMMUP00000044820	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Claspin.	0.621
ATM	TP53	ENSMMUP00000005561	ENSMMUP00000011334	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.999
ATM	WEE1	ENSMMUP00000005561	ENSMMUP00000011479	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Wee1-like protein kinase.	0.596
ATR	ATM	ENSMMUP00000010409	ENSMMUP00000005561	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.999
ATR	CDC25A	ENSMMUP00000010409	ENSMMUP00000027572	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	M-phase inducer phosphatase 1 isoform a.	0.588
ATR	CDC25B	ENSMMUP00000010409	ENSMMUP00000042435	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Cell division cycle 25B.	0.588
ATR	CDC25C	ENSMMUP00000010409	ENSMMUP00000011824	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Cell division cycle 25C.	0.588
ATR	CHEK1	ENSMMUP00000010409	ENSMMUP00000036602	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	STT3 oligosaccharyltransferase complex catalytic subunit A.	0.998
ATR	CHEK2	ENSMMUP00000010409	ENSMMUP00000037133	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Checkpoint kinase 2.	0.992
ATR	CLSPN	ENSMMUP00000010409	ENSMMUP00000044820	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Claspin.	0.801
ATR	TP53	ENSMMUP00000010409	ENSMMUP00000011334	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.979
ATR	WEE1	ENSMMUP00000010409	ENSMMUP00000011479	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Wee1-like protein kinase.	0.496
ATR	WEE2	ENSMMUP00000010409	ENSMMUP00000055706	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Wee1-like protein kinase.	0.493
CDC25A	ATM	ENSMMUP00000027572	ENSMMUP00000005561	M-phase inducer phosphatase 1 isoform a.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.631
CDC25A	ATR	ENSMMUP00000027572	ENSMMUP00000010409	M-phase inducer phosphatase 1 isoform a.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.588