PTPN22 protein (Macaca mulatta) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSK	EGFR	ENSMMUP00000071007	ENSMMUP00000046120	Tyrosine-protein kinase.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.949
CSK	LCK	ENSMMUP00000071007	ENSMMUP00000044699	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.771
CSK	MATK	ENSMMUP00000071007	ENSMMUP00000079139	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.502
CSK	PTPN22	ENSMMUP00000071007	ENSMMUP00000053568	Tyrosine-protein kinase.	Protein tyrosine phosphatase non-receptor type 22.	0.915
CSK	SHC1	ENSMMUP00000071007	ENSMMUP00000008658	Tyrosine-protein kinase.	SHC-transforming protein 1 isoform 3.	0.868
CSK	SHC3	ENSMMUP00000071007	ENSMMUP00000049326	Tyrosine-protein kinase.	Uncharacterized protein.	0.691
CSK	ZAP70	ENSMMUP00000071007	ENSMMUP00000028374	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.513
EGFR	CSK	ENSMMUP00000046120	ENSMMUP00000071007	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Tyrosine-protein kinase.	0.949
EGFR	LCK	ENSMMUP00000046120	ENSMMUP00000044699	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Tyrosine-protein kinase.	0.760
EGFR	MATK	ENSMMUP00000046120	ENSMMUP00000079139	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Tyrosine-protein kinase.	0.818
EGFR	PTPN22	ENSMMUP00000046120	ENSMMUP00000053568	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Protein tyrosine phosphatase non-receptor type 22.	0.888
EGFR	SHC1	ENSMMUP00000046120	ENSMMUP00000008658	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	SHC-transforming protein 1 isoform 3.	0.995
EGFR	SHC3	ENSMMUP00000046120	ENSMMUP00000049326	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Uncharacterized protein.	0.986
EGFR	ZAP70	ENSMMUP00000046120	ENSMMUP00000028374	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Tyrosine-protein kinase.	0.767
GDE1	PTPN22	ENSMMUP00000017526	ENSMMUP00000053568	Glycerophosphodiester phosphodiesterase 1.	Protein tyrosine phosphatase non-receptor type 22.	0.708
LCK	CSK	ENSMMUP00000044699	ENSMMUP00000071007	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.771
LCK	EGFR	ENSMMUP00000044699	ENSMMUP00000046120	Tyrosine-protein kinase.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.760
LCK	MATK	ENSMMUP00000044699	ENSMMUP00000079139	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.638
LCK	PTPN22	ENSMMUP00000044699	ENSMMUP00000053568	Tyrosine-protein kinase.	Protein tyrosine phosphatase non-receptor type 22.	0.817
LCK	SHC1	ENSMMUP00000044699	ENSMMUP00000008658	Tyrosine-protein kinase.	SHC-transforming protein 1 isoform 3.	0.681