PIK3R3 protein (Macaca mulatta) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

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[Homology]

Score

PIK3R3

Uncharacterized protein. (507 aa)

Predicted Functional Partners:

PIK3CB

0.996

PIK3CA

0.995

PIK3CD

0.993

PIK3CG

0.987

PIK3R2

0.986

PIK3R1

0.986

IRS1

0.983

EGFR

0.974

CBL

0.973

IRS2

0.970

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBL	EGFR	ENSMMUP00000059041	ENSMMUP00000046120	E3 ubiquitin-protein ligase CBL.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.999
CBL	IRS1	ENSMMUP00000059041	ENSMMUP00000045227	E3 ubiquitin-protein ligase CBL.	Insulin receptor substrate 1.	0.401
CBL	PIK3CA	ENSMMUP00000059041	ENSMMUP00000006866	E3 ubiquitin-protein ligase CBL.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.956
CBL	PIK3CB	ENSMMUP00000059041	ENSMMUP00000011365	E3 ubiquitin-protein ligase CBL.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.957
CBL	PIK3CD	ENSMMUP00000059041	ENSMMUP00000068489	E3 ubiquitin-protein ligase CBL.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.947
CBL	PIK3CG	ENSMMUP00000059041	ENSMMUP00000066301	E3 ubiquitin-protein ligase CBL.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family.	0.430
CBL	PIK3R1	ENSMMUP00000059041	ENSMMUP00000015140	E3 ubiquitin-protein ligase CBL.	Phosphoinositide-3-kinase regulatory subunit 1.	0.995
CBL	PIK3R2	ENSMMUP00000059041	ENSMMUP00000004228	E3 ubiquitin-protein ligase CBL.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.972
CBL	PIK3R3	ENSMMUP00000059041	ENSMMUP00000060463	E3 ubiquitin-protein ligase CBL.	Uncharacterized protein.	0.973
EGFR	CBL	ENSMMUP00000046120	ENSMMUP00000059041	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	E3 ubiquitin-protein ligase CBL.	0.999
EGFR	IRS1	ENSMMUP00000046120	ENSMMUP00000045227	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Insulin receptor substrate 1.	0.813
EGFR	PIK3CA	ENSMMUP00000046120	ENSMMUP00000006866	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.992
EGFR	PIK3CB	ENSMMUP00000046120	ENSMMUP00000011365	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.972
EGFR	PIK3CD	ENSMMUP00000046120	ENSMMUP00000068489	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.945
EGFR	PIK3CG	ENSMMUP00000046120	ENSMMUP00000066301	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family.	0.563
EGFR	PIK3R1	ENSMMUP00000046120	ENSMMUP00000015140	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Phosphoinositide-3-kinase regulatory subunit 1.	0.990
EGFR	PIK3R2	ENSMMUP00000046120	ENSMMUP00000004228	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.975
EGFR	PIK3R3	ENSMMUP00000046120	ENSMMUP00000060463	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Uncharacterized protein.	0.974
IRS1	CBL	ENSMMUP00000045227	ENSMMUP00000059041	Insulin receptor substrate 1.	E3 ubiquitin-protein ligase CBL.	0.401
IRS1	EGFR	ENSMMUP00000045227	ENSMMUP00000046120	Insulin receptor substrate 1.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.813