MAPK10 protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DUSP10	FOS	ENSMMUP00000005852	ENSMMUP00000071593	Dual specificity protein phosphatase 10 isoform a; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	0.527
DUSP10	JUN	ENSMMUP00000005852	ENSMMUP00000074392	Dual specificity protein phosphatase 10 isoform a; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Transcription factor AP-1; Belongs to the bZIP family.	0.525
DUSP10	MAPK10	ENSMMUP00000005852	ENSMMUP00000042171	Dual specificity protein phosphatase 10 isoform a; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.977
DUSP10	MAPK9	ENSMMUP00000005852	ENSMMUP00000002308	Dual specificity protein phosphatase 10 isoform a; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.978
DUSP4	FOS	ENSMMUP00000072613	ENSMMUP00000071593	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	0.605
DUSP4	JUN	ENSMMUP00000072613	ENSMMUP00000074392	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Transcription factor AP-1; Belongs to the bZIP family.	0.516
DUSP4	MAPK10	ENSMMUP00000072613	ENSMMUP00000042171	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.982
DUSP4	MAPK9	ENSMMUP00000072613	ENSMMUP00000002308	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Mitogen-activated protein kinase.	0.954
DUSP8	FOS	ENSMMUP00000080867	ENSMMUP00000071593	Dual specificity phosphatase 8.	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	0.453
DUSP8	JUN	ENSMMUP00000080867	ENSMMUP00000074392	Dual specificity phosphatase 8.	Transcription factor AP-1; Belongs to the bZIP family.	0.535
DUSP8	MAPK10	ENSMMUP00000080867	ENSMMUP00000042171	Dual specificity phosphatase 8.	Mitogen-activated protein kinase.	0.976
DUSP8	MAPK9	ENSMMUP00000080867	ENSMMUP00000002308	Dual specificity phosphatase 8.	Mitogen-activated protein kinase.	0.962
FOS	DUSP10	ENSMMUP00000071593	ENSMMUP00000005852	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	Dual specificity protein phosphatase 10 isoform a; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.527
FOS	DUSP4	ENSMMUP00000071593	ENSMMUP00000072613	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.605
FOS	DUSP8	ENSMMUP00000071593	ENSMMUP00000080867	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	Dual specificity phosphatase 8.	0.453
FOS	FOSL1	ENSMMUP00000071593	ENSMMUP00000053204	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	FOS like 1, AP-1 transcription factor subunit.	0.956
FOS	JUN	ENSMMUP00000071593	ENSMMUP00000074392	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	Transcription factor AP-1; Belongs to the bZIP family.	0.999
FOS	MAPK10	ENSMMUP00000071593	ENSMMUP00000042171	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	Mitogen-activated protein kinase.	0.988
FOS	MAPK9	ENSMMUP00000071593	ENSMMUP00000002308	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	Mitogen-activated protein kinase.	0.990
FOS	TP53	ENSMMUP00000071593	ENSMMUP00000011334	V-fos FBJ murine osteosarcoma viral oncogene-like protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.749