PCSK1 protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PCSK1

Neuroendocrine convertase 1 isoform 1 preproprotein; Belongs to the peptidase S8 family. (749 aa)

Predicted Functional Partners:

POMC

0.823

LIPG

0.775

INS

0.757

GHRL

0.741

NHLH2

0.728

USP24

0.716

BSND

0.691

MC4R

0.661

PCSK1N

0.617

CARTPT

0.608

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BSND	LIPG	ENSMMUP00000007571	ENSMMUP00000025049	Barttin CLCNK type accessory beta subunit.	Lipase G, endothelial type.	0.570
BSND	PCSK1	ENSMMUP00000007571	ENSMMUP00000044810	Barttin CLCNK type accessory beta subunit.	Neuroendocrine convertase 1 isoform 1 preproprotein; Belongs to the peptidase S8 family.	0.691
BSND	USP24	ENSMMUP00000007571	ENSMMUP00000007577	Barttin CLCNK type accessory beta subunit.	Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family.	0.813
CARTPT	PCSK1	ENSMMUP00000071720	ENSMMUP00000044810	CART prepropeptide.	Neuroendocrine convertase 1 isoform 1 preproprotein; Belongs to the peptidase S8 family.	0.608
CARTPT	POMC	ENSMMUP00000071720	ENSMMUP00000075833	CART prepropeptide.	Uncharacterized protein.	0.553
GHRL	INS	ENSMMUP00000062710	ENSMMUP00000037777	Ghrelin and obestatin prepropeptide.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.970
GHRL	MC4R	ENSMMUP00000062710	ENSMMUP00000022705	Ghrelin and obestatin prepropeptide.	Melanocortin 4 receptor.	0.825
GHRL	PCSK1	ENSMMUP00000062710	ENSMMUP00000044810	Ghrelin and obestatin prepropeptide.	Neuroendocrine convertase 1 isoform 1 preproprotein; Belongs to the peptidase S8 family.	0.741
GHRL	POMC	ENSMMUP00000062710	ENSMMUP00000075833	Ghrelin and obestatin prepropeptide.	Uncharacterized protein.	0.880
INS	GHRL	ENSMMUP00000037777	ENSMMUP00000062710	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Ghrelin and obestatin prepropeptide.	0.970
INS	MC4R	ENSMMUP00000037777	ENSMMUP00000022705	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Melanocortin 4 receptor.	0.685
INS	PCSK1	ENSMMUP00000037777	ENSMMUP00000044810	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Neuroendocrine convertase 1 isoform 1 preproprotein; Belongs to the peptidase S8 family.	0.757
INS	POMC	ENSMMUP00000037777	ENSMMUP00000075833	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.831
LIPG	BSND	ENSMMUP00000025049	ENSMMUP00000007571	Lipase G, endothelial type.	Barttin CLCNK type accessory beta subunit.	0.570
LIPG	PCSK1	ENSMMUP00000025049	ENSMMUP00000044810	Lipase G, endothelial type.	Neuroendocrine convertase 1 isoform 1 preproprotein; Belongs to the peptidase S8 family.	0.775
LIPG	USP24	ENSMMUP00000025049	ENSMMUP00000007577	Lipase G, endothelial type.	Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family.	0.689
MC4R	GHRL	ENSMMUP00000022705	ENSMMUP00000062710	Melanocortin 4 receptor.	Ghrelin and obestatin prepropeptide.	0.825
MC4R	INS	ENSMMUP00000022705	ENSMMUP00000037777	Melanocortin 4 receptor.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.685
MC4R	PCSK1	ENSMMUP00000022705	ENSMMUP00000044810	Melanocortin 4 receptor.	Neuroendocrine convertase 1 isoform 1 preproprotein; Belongs to the peptidase S8 family.	0.661
MC4R	POMC	ENSMMUP00000022705	ENSMMUP00000075833	Melanocortin 4 receptor.	Uncharacterized protein.	0.996