EGFR protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

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co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

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Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBL	EGF	ENSMMUP00000059041	ENSMMUP00000013132	E3 ubiquitin-protein ligase CBL.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.548
CBL	EGFR	ENSMMUP00000059041	ENSMMUP00000046120	E3 ubiquitin-protein ligase CBL.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.999
CBL	GRB2	ENSMMUP00000059041	ENSMMUP00000045339	E3 ubiquitin-protein ligase CBL.	Growth factor receptor-bound protein 2 isoform 1.	0.996
CBL	HBEGF	ENSMMUP00000059041	ENSMMUP00000062333	E3 ubiquitin-protein ligase CBL.	EGF-like domain-containing protein.	0.548
CBL	PIK3CA	ENSMMUP00000059041	ENSMMUP00000006866	E3 ubiquitin-protein ligase CBL.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.989
CBL	PIK3R1	ENSMMUP00000059041	ENSMMUP00000015140	E3 ubiquitin-protein ligase CBL.	Phosphoinositide-3-kinase regulatory subunit 1.	0.995
CBL	PTPN11	ENSMMUP00000059041	ENSMMUP00000050217	E3 ubiquitin-protein ligase CBL.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.915
CBL	SRC	ENSMMUP00000059041	ENSMMUP00000026506	E3 ubiquitin-protein ligase CBL.	Tyrosine-protein kinase.	0.973
CBL	STAT3	ENSMMUP00000059041	ENSMMUP00000043986	E3 ubiquitin-protein ligase CBL.	Signal transducer and activator of transcription.	0.680
CBL	TGFA	ENSMMUP00000059041	ENSMMUP00000045964	E3 ubiquitin-protein ligase CBL.	Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.	0.467
EGF	CBL	ENSMMUP00000013132	ENSMMUP00000059041	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	E3 ubiquitin-protein ligase CBL.	0.548
EGF	EGFR	ENSMMUP00000013132	ENSMMUP00000046120	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.999
EGF	GRB2	ENSMMUP00000013132	ENSMMUP00000045339	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Growth factor receptor-bound protein 2 isoform 1.	0.738
EGF	HBEGF	ENSMMUP00000013132	ENSMMUP00000062333	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	EGF-like domain-containing protein.	0.856
EGF	PIK3CA	ENSMMUP00000013132	ENSMMUP00000006866	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.811
EGF	PIK3R1	ENSMMUP00000013132	ENSMMUP00000015140	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Phosphoinositide-3-kinase regulatory subunit 1.	0.654
EGF	PTPN11	ENSMMUP00000013132	ENSMMUP00000050217	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.710
EGF	SRC	ENSMMUP00000013132	ENSMMUP00000026506	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Tyrosine-protein kinase.	0.801
EGF	STAT3	ENSMMUP00000013132	ENSMMUP00000043986	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Signal transducer and activator of transcription.	0.733
EGF	TGFA	ENSMMUP00000013132	ENSMMUP00000045964	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.	0.971