STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NGFNerve growth factor; Belongs to the NGF-beta family. (294 aa)    
Predicted Functional Partners:
NTRK1
Tyrosine-protein kinase receptor.
    
 0.997
NGFR
Nerve growth factor receptor.
    
 0.977
NTRK2
Tyrosine-protein kinase receptor.
    
 0.967
BDNF
Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]
    
0.910
NTRK3
Tyrosine-protein kinase receptor.
    
 0.902
SORCS2
Sortilin related VPS10 domain containing receptor 2.
    
 
 0.885
GDNF
Glial cell derived neurotrophic factor.
      
 0.859
SORT1
Sortilin.
    
 
 0.847
NRTN
Neurturin preproprotein.
      
 0.835
IGF1R
Tyrosine-protein kinase receptor.
    
 0.783
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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