STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)    
Predicted Functional Partners:
RHOA
Ras homolog family member A.
   
 0.999
ROCK2
Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
  
0.983
PPP1R12A
Protein phosphatase 1 regulatory subunit.
   
 0.976
RND3
Rho-related GTP-binding protein RhoE.
   
 0.961
LIMK2
LIM domain kinase 2.
   
0.950
LIMK1
LIM domain kinase 1 isoform 1.
   
0.948
PTEN
Uncharacterized protein.
   
 0.945
CTNNB1
Catenin beta-1.
   
 0.945
PPP1R12C
Protein phosphatase 1 regulatory subunit.
   
 0.938
PPP1CB
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
   
 0.936
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.