STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NKX3-1Homeobox protein Nkx-3.1. (232 aa)    
Predicted Functional Partners:
AKT3
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
     
 0.911
AKT1
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
     
 0.910
AKT2
AKT serine/threonine kinase 2.
     
 0.904
RNF25
Ring finger protein 25.
      
 0.604
DHRS12
Dehydrogenase/reductase 12.
      
 0.597
TMEM225
Uncharacterized protein.
      
 0.597
PATZ1
POZ/BTB and AT hook containing zinc finger 1.
      
 0.593
AR
Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
    
 
 0.582
SPDEF
SAM pointed domain containing ETS transcription factor.
    
 
 0.552
TMCO5A
Transmembrane and coiled-coil domains 5A.
      
 0.540
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.