STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HLA-DRAMamu class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (378 aa)    
Predicted Functional Partners:
CD74
HLA class II histocompatibility antigen gamma chain isoform a.
   
 0.998
HLA-DRB5
Ig-like domain-containing protein.
   
0.992
MAMU-DMA
Ig-like domain-containing protein.
   
0.987
CD4
T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]
   
 0.987
ENSMMUP00000068350
MHC_II_beta domain-containing protein.
   
 0.967
MAMU-DPA
MHC class II antigen; Belongs to the MHC class II family.
  
 
0.962
LOC114669810
Ig-like domain-containing protein; Belongs to the MHC class II family.
  
 
0.958
CD247
CD247 molecule.
   
 
 0.956
ENSMMUP00000076578
Ig-like domain-containing protein.
    
  0.940
ENSMMUP00000017083
Ig-like domain-containing protein.
   
 0.934
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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