STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PKN1Protein kinase N1. (1013 aa)    
Predicted Functional Partners:
RHOA
Ras homolog family member A.
   
 0.997
PDPK1
3-phosphoinositide dependent protein kinase 1.
    
0.964
MEFV
MEFV innate immuity regulator, pyrin.
   
 0.944
PKN2
Protein kinase N2.
  
 
 
0.932
PKN3
Protein kinase N3.
  
  
 
0.926
YWHAE
14-3-3 protein epsilon; Belongs to the 14-3-3 family.
    
 0.877
AR
Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
   
 0.685
F7B371_MACMU
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
0.660
NCOA2
Nuclear receptor coactivator.
   
 
 0.658
MAP3K20
Mitogen-activated protein kinase kinase kinase MLT isoform 1.
   
0.622
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.