STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CBLE3 ubiquitin-protein ligase CBL. (907 aa)    
Predicted Functional Partners:
EGFR
Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]
    
 0.999
MET
Uncharacterized protein.
   
 0.996
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
    
 0.995
CRK
CRK proto-oncogene, adaptor protein.
    
 0.995
GRB2
Growth factor receptor-bound protein 2 isoform 1.
    
 0.995
SPRY2
Sprouty RTK signaling antagonist 2.
    
 0.986
RAPGEF1
Rap guanine nucleotide exchange factor 1.
    
 0.984
SH3KBP1
SH3 domain containing kinase binding protein 1.
   
 0.981
ABL1
Tyrosine-protein kinase.
   
 0.978
SH2B2
SH2B adaptor protein 2.
   
 0.973
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.