GAB2 protein (Macaca mulatta) - STRING interaction network

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Score

GAB2

GRB2 associated binding protein 2. (677 aa)

Predicted Functional Partners:

GRB2

0.997

PTPN11

0.992

PIK3R1

0.975

SOS1

0.957

SOS2

0.953

PIK3R2

0.950

PIK3R3

0.944

SYK

0.944

EGFR

0.941

LYN

0.940

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	GAB2	ENSMMUP00000046120	ENSMMUP00000059153	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	GRB2 associated binding protein 2.	0.941
EGFR	GRB2	ENSMMUP00000046120	ENSMMUP00000045339	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Growth factor receptor-bound protein 2 isoform 1.	0.999
EGFR	LYN	ENSMMUP00000046120	ENSMMUP00000052162	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Tyrosine-protein kinase.	0.683
EGFR	PIK3R1	ENSMMUP00000046120	ENSMMUP00000015140	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Phosphoinositide-3-kinase regulatory subunit 1.	0.990
EGFR	PIK3R2	ENSMMUP00000046120	ENSMMUP00000004228	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.975
EGFR	PIK3R3	ENSMMUP00000046120	ENSMMUP00000060463	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Uncharacterized protein.	0.974
EGFR	PTPN11	ENSMMUP00000046120	ENSMMUP00000050217	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.998
EGFR	SOS1	ENSMMUP00000046120	ENSMMUP00000066881	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.997
EGFR	SOS2	ENSMMUP00000046120	ENSMMUP00000046283	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Uncharacterized protein.	0.985
GAB2	EGFR	ENSMMUP00000059153	ENSMMUP00000046120	GRB2 associated binding protein 2.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.941
GAB2	GRB2	ENSMMUP00000059153	ENSMMUP00000045339	GRB2 associated binding protein 2.	Growth factor receptor-bound protein 2 isoform 1.	0.997
GAB2	LYN	ENSMMUP00000059153	ENSMMUP00000052162	GRB2 associated binding protein 2.	Tyrosine-protein kinase.	0.940
GAB2	PIK3R1	ENSMMUP00000059153	ENSMMUP00000015140	GRB2 associated binding protein 2.	Phosphoinositide-3-kinase regulatory subunit 1.	0.975
GAB2	PIK3R2	ENSMMUP00000059153	ENSMMUP00000004228	GRB2 associated binding protein 2.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.950
GAB2	PIK3R3	ENSMMUP00000059153	ENSMMUP00000060463	GRB2 associated binding protein 2.	Uncharacterized protein.	0.944
GAB2	PTPN11	ENSMMUP00000059153	ENSMMUP00000050217	GRB2 associated binding protein 2.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.992
GAB2	SOS1	ENSMMUP00000059153	ENSMMUP00000066881	GRB2 associated binding protein 2.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.957
GAB2	SOS2	ENSMMUP00000059153	ENSMMUP00000046283	GRB2 associated binding protein 2.	Uncharacterized protein.	0.953
GAB2	SYK	ENSMMUP00000059153	ENSMMUP00000063860	GRB2 associated binding protein 2.	Tyrosine-protein kinase.	0.944
GRB2	EGFR	ENSMMUP00000045339	ENSMMUP00000046120	Growth factor receptor-bound protein 2 isoform 1.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.999