| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AOX1 | CES2 | ENSMMUP00000051769 | ENSMMUP00000081248 | Aldehyde oxidase 1. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.488 |
| AOX1 | CYP1A1 | ENSMMUP00000051769 | ENSMMUP00000029575 | Aldehyde oxidase 1. | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | 0.923 |
| AOX1 | CYP2A23 | ENSMMUP00000051769 | ENSMMUP00000079626 | Aldehyde oxidase 1. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.475 |
| AOX1 | CYP2B6 | ENSMMUP00000051769 | ENSMMUP00000024146 | Aldehyde oxidase 1. | Cytochrome P450 CYP2B30; Belongs to the cytochrome P450 family. | 0.941 |
| AOX1 | CYP2D42 | ENSMMUP00000051769 | ENSMMUP00000023613 | Aldehyde oxidase 1. | Cytochrome P450 CYP2D42; Belongs to the cytochrome P450 family. | 0.566 |
| AOX1 | CYP2E1 | ENSMMUP00000051769 | ENSMMUP00000049288 | Aldehyde oxidase 1. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.504 |
| AOX1 | CYP3A4 | ENSMMUP00000051769 | ENSMMUP00000004730 | Aldehyde oxidase 1. | Uncharacterized protein. | 0.951 |
| AOX1 | UGT2B7 | ENSMMUP00000051769 | ENSMMUP00000060516 | Aldehyde oxidase 1. | UDP-glucuronosyltransferase 2B33; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on estriol and does not catalyze the glucuronidation of beta-estradiol. Capable of conjugating 4-hydroxyestrone, androsterone, diclofenac, and hyodeoxycholic acid. | 0.935 |
| CES2 | AOX1 | ENSMMUP00000081248 | ENSMMUP00000051769 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Aldehyde oxidase 1. | 0.488 |
| CES2 | UGT2B7 | ENSMMUP00000081248 | ENSMMUP00000060516 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | UDP-glucuronosyltransferase 2B33; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on estriol and does not catalyze the glucuronidation of beta-estradiol. Capable of conjugating 4-hydroxyestrone, androsterone, diclofenac, and hyodeoxycholic acid. | 0.937 |
| COMT | CYP1A1 | ENSMMUP00000066080 | ENSMMUP00000029575 | Catechol-O-methyltransferase. | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | 0.951 |
| COMT | CYP1B1 | ENSMMUP00000066080 | ENSMMUP00000018330 | Catechol-O-methyltransferase. | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.958 |
| COMT | CYP2D42 | ENSMMUP00000066080 | ENSMMUP00000023613 | Catechol-O-methyltransferase. | Cytochrome P450 CYP2D42; Belongs to the cytochrome P450 family. | 0.455 |
| COMT | UGT2B7 | ENSMMUP00000066080 | ENSMMUP00000060516 | Catechol-O-methyltransferase. | UDP-glucuronosyltransferase 2B33; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on estriol and does not catalyze the glucuronidation of beta-estradiol. Capable of conjugating 4-hydroxyestrone, androsterone, diclofenac, and hyodeoxycholic acid. | 0.934 |
| CYP1A1 | AOX1 | ENSMMUP00000029575 | ENSMMUP00000051769 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Aldehyde oxidase 1. | 0.923 |
| CYP1A1 | COMT | ENSMMUP00000029575 | ENSMMUP00000066080 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Catechol-O-methyltransferase. | 0.951 |
| CYP1A1 | CYP1B1 | ENSMMUP00000029575 | ENSMMUP00000018330 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.942 |
| CYP1A1 | CYP2A23 | ENSMMUP00000029575 | ENSMMUP00000079626 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Uncharacterized protein; Belongs to the cytochrome P450 family. | 0.934 |
| CYP1A1 | CYP2B6 | ENSMMUP00000029575 | ENSMMUP00000024146 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Cytochrome P450 CYP2B30; Belongs to the cytochrome P450 family. | 0.936 |
| CYP1A1 | CYP2D42 | ENSMMUP00000029575 | ENSMMUP00000023613 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Cytochrome P450 CYP2D42; Belongs to the cytochrome P450 family. | 0.937 |
