STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HIPK3Homeodomain-interacting protein kinase 3 isoform 1. (1215 aa)    
Predicted Functional Partners:
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
    
 0.969
RASSF5
Ras association domain family member 5.
    
 0.907
ARFGEF1
ADP ribosylation factor guanine nucleotide exchange factor 1.
   
 
 0.658
FAF1
FAS-associated factor 1.
      
 0.603
ZNF609
C2H2-type domain-containing protein.
   
  
 0.576
ANKRD52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C.
    
 
 0.571
CAMSAP1
Calmodulin regulated spectrin associated protein 1.
   
 
 0.552
ANKRD17
Ankyrin repeat domain 17.
    
 
 0.545
PIN1
Peptidyl-prolyl cis-trans isomerase.
    
 0.544
ITCH
E3 ubiquitin-protein ligase.
    
 
 0.529
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.