GRK3 protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB1	ARRB2	ENSMMUP00000077529	ENSMMUP00000067243	Arrestin beta 1.	Arrestin beta 2.	0.993
ARRB1	GRK2	ENSMMUP00000077529	ENSMMUP00000052766	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.983
ARRB1	GRK3	ENSMMUP00000077529	ENSMMUP00000064465	Arrestin beta 1.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.934
ARRB1	OPRM1	ENSMMUP00000077529	ENSMMUP00000043883	Arrestin beta 1.	Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...]	0.934
ARRB1	SMO	ENSMMUP00000077529	ENSMMUP00000015878	Arrestin beta 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.981
ARRB2	ARRB1	ENSMMUP00000067243	ENSMMUP00000077529	Arrestin beta 2.	Arrestin beta 1.	0.993
ARRB2	GRK2	ENSMMUP00000067243	ENSMMUP00000052766	Arrestin beta 2.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.985
ARRB2	GRK3	ENSMMUP00000067243	ENSMMUP00000064465	Arrestin beta 2.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.946
ARRB2	OPRM1	ENSMMUP00000067243	ENSMMUP00000043883	Arrestin beta 2.	Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...]	0.934
ARRB2	SMO	ENSMMUP00000067243	ENSMMUP00000015878	Arrestin beta 2.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.982
CSNK1A1	CSNK1A1L	ENSMMUP00000078924	ENSMMUP00000006638	Casein kinase I isoform alpha isoform 1; Belongs to the protein kinase superfamily.	Casein kinase I isoform alpha-like protein; Belongs to the protein kinase superfamily.	0.900
CSNK1A1	GRK2	ENSMMUP00000078924	ENSMMUP00000052766	Casein kinase I isoform alpha isoform 1; Belongs to the protein kinase superfamily.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.952
CSNK1A1	GRK3	ENSMMUP00000078924	ENSMMUP00000064465	Casein kinase I isoform alpha isoform 1; Belongs to the protein kinase superfamily.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.952
CSNK1A1	SMO	ENSMMUP00000078924	ENSMMUP00000015878	Casein kinase I isoform alpha isoform 1; Belongs to the protein kinase superfamily.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.964
CSNK1A1L	CSNK1A1	ENSMMUP00000006638	ENSMMUP00000078924	Casein kinase I isoform alpha-like protein; Belongs to the protein kinase superfamily.	Casein kinase I isoform alpha isoform 1; Belongs to the protein kinase superfamily.	0.900
CSNK1A1L	GRK2	ENSMMUP00000006638	ENSMMUP00000052766	Casein kinase I isoform alpha-like protein; Belongs to the protein kinase superfamily.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.952
CSNK1A1L	GRK3	ENSMMUP00000006638	ENSMMUP00000064465	Casein kinase I isoform alpha-like protein; Belongs to the protein kinase superfamily.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.952
CSNK1A1L	SMO	ENSMMUP00000006638	ENSMMUP00000015878	Casein kinase I isoform alpha-like protein; Belongs to the protein kinase superfamily.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.964
CSNK1G1	CSNK1G2	ENSMMUP00000027811	ENSMMUP00000008701	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Casein kinase 1 gamma 2.	0.807
CSNK1G1	CSNK1G3	ENSMMUP00000027811	ENSMMUP00000008742	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.807