STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TTYH3Protein tweety homolog; Probable chloride channel. (611 aa)    
Predicted Functional Partners:
ZNF467
Zinc finger protein 467.
     
 0.827
TBC1D8
TBC1 domain family member 8.
      
 0.688
ZBTB4
Zinc finger and BTB domain containing 4.
      
 0.641
HIC1
HIC ZBTB transcriptional repressor 1.
   
  
 0.591
LGSN
Lengsin, lens protein with glutamine synthetase domain; Belongs to the glutamine synthetase family.
      
 0.582
FAM78A
Family with sequence similarity 78 member A.
      
 0.581
LRRC8C
Leucine-rich repeat-containing protein 8C.
      
 0.552
KCP
Kielin cysteine rich BMP regulator.
   
  
 0.508
LRRC8E
Leucine rich repeat containing 8 VRAC subunit E.
      
 0.507
IMPDH1
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
   
  
 0.480
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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