STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC716637RBR-type E3 ubiquitin transferase. (333 aa)    
Predicted Functional Partners:
TNF
Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]
   
 0.552
UBA52
Ubiquitin-60S ribosomal protein L40.
    
  0.523
CYLD
CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.
    
 0.522
NFATC4
Nuclear factor of activated T cells 4.
    
 0.522
BIRC6
Baculoviral IAP repeat containing 6.
   
 0.518
OTULINL
OTU deubiquitinase with linear linkage specificity like.
    
 0.489
OTULIN
Uncharacterized protein.
    
 0.489
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
    
 0.486
OPTN
Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...]
    
 0.486
CUL5
Cullin 5; Belongs to the cullin family.
    
 
 0.452
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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