node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASIP | GRAP2 | ENSMMUP00000077604 | ENSMMUP00000066911 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | GRB2 related adaptor protein 2. | 0.481 |
ASIP | OCA2 | ENSMMUP00000077604 | ENSMMUP00000015778 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | OCA2 melanosomal transmembrane protein. | 0.715 |
ASIP | SLC16A9 | ENSMMUP00000077604 | ENSMMUP00000073023 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Solute carrier family 16 member 9. | 0.687 |
ASIP | SLC24A4 | ENSMMUP00000077604 | ENSMMUP00000018349 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.543 |
ASIP | SLC25A48 | ENSMMUP00000077604 | ENSMMUP00000002605 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Solute carrier family 25 member 48; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.689 |
ASIP | SLC47A2 | ENSMMUP00000077604 | ENSMMUP00000050454 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Multidrug and toxin extrusion protein; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. | 0.472 |
ASIP | TYRP1 | ENSMMUP00000077604 | ENSMMUP00000071668 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | Tyrosinase related protein 1. | 0.738 |
EMB | SLC16A9 | ENSMMUP00000063751 | ENSMMUP00000073023 | Embigin. | Solute carrier family 16 member 9. | 0.538 |
GRAP2 | ASIP | ENSMMUP00000066911 | ENSMMUP00000077604 | GRB2 related adaptor protein 2. | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | 0.481 |
GRAP2 | IRF6 | ENSMMUP00000066911 | ENSMMUP00000029056 | GRB2 related adaptor protein 2. | Interferon regulatory factor 6 isoform 1. | 0.402 |
GRAP2 | SLC16A9 | ENSMMUP00000066911 | ENSMMUP00000073023 | GRB2 related adaptor protein 2. | Solute carrier family 16 member 9. | 0.650 |
GRAP2 | SLC24A4 | ENSMMUP00000066911 | ENSMMUP00000018349 | GRB2 related adaptor protein 2. | Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.438 |
GRAP2 | SLC25A48 | ENSMMUP00000066911 | ENSMMUP00000002605 | GRB2 related adaptor protein 2. | Solute carrier family 25 member 48; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.694 |
GRAP2 | SLC47A2 | ENSMMUP00000066911 | ENSMMUP00000050454 | GRB2 related adaptor protein 2. | Multidrug and toxin extrusion protein; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. | 0.508 |
GRAP2 | TYRP1 | ENSMMUP00000066911 | ENSMMUP00000071668 | GRB2 related adaptor protein 2. | Tyrosinase related protein 1. | 0.421 |
IRF6 | GRAP2 | ENSMMUP00000029056 | ENSMMUP00000066911 | Interferon regulatory factor 6 isoform 1. | GRB2 related adaptor protein 2. | 0.402 |
IRF6 | SLC16A9 | ENSMMUP00000029056 | ENSMMUP00000073023 | Interferon regulatory factor 6 isoform 1. | Solute carrier family 16 member 9. | 0.533 |
IRF6 | SLC25A48 | ENSMMUP00000029056 | ENSMMUP00000002605 | Interferon regulatory factor 6 isoform 1. | Solute carrier family 25 member 48; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.539 |
OCA2 | ASIP | ENSMMUP00000015778 | ENSMMUP00000077604 | OCA2 melanosomal transmembrane protein. | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). | 0.715 |
OCA2 | SLC16A9 | ENSMMUP00000015778 | ENSMMUP00000073023 | OCA2 melanosomal transmembrane protein. | Solute carrier family 16 member 9. | 0.588 |