STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)    
Predicted Functional Partners:
TRIP12
Thyroid hormone receptor interactor 12.
   
 0.972
UBE2A
Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.796
UBE2B
Ubiquitin-conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.716
UBR4
Ubiquitin protein ligase E3 component n-recognin 4.
   
  
 0.710
UBE2U
Ubiquitin conjugating enzyme E2 U; Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.658
UBB
Uncharacterized protein.
   
 0.658
UBC
Uncharacterized protein.
   
 0.657
HUWE1
E3 ubiquitin-protein ligase HUWE1.
   
 
 0.632
MARCHF6
Membrane associated ring-CH-type finger 6.
   
 
 0.620
LTN1
Listerin E3 ubiquitin protein ligase 1.
   
 0.607
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.