STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C4H6orf58Uncharacterized protein. (330 aa)    
Predicted Functional Partners:
KIAA0408
DUF4482 domain-containing protein.
      
 0.781
SPPL3
Uncharacterized protein.
      
 0.780
CDK11B
Protein kinase domain-containing protein.
      
 0.750
TMED1
Uncharacterized protein.
      
 0.746
RNF146
E3 ubiquitin-protein ligase RNF146 isoform b.
      
 0.736
MMACHC
Methylmalonic aciduria and homocystinuria type C protein.
   
  
 0.732
BPIFB1
BPI1 domain-containing protein.
   
  
 0.715
SCARA5
Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the de [...]
   
  
 0.597
MAP3K11
Mitogen-activated protein kinase kinase kinase.
      
 0.596
DOK2
Docking protein 2.
      
 0.594
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.