STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLK14Kallikrein related peptidase 14; Belongs to the peptidase S1 family. (267 aa)    
Predicted Functional Partners:
SPINK5
Serine peptidase inhibitor, Kazal type 5.
    
 0.821
SPINK6
Serine peptidase inhibitor, Kazal type 6.
    
 0.758
TGM4
Transglutaminase 4.
     
 0.634
SERPINA5
SERPIN domain-containing protein; Belongs to the serpin family.
    
 0.629
SPINK13
Epididymis-specific trypsin inhibitor-like protein.
    
 0.599
PATE4
Uncharacterized protein.
      
 0.595
CDSN
Corneodesmosin; Important for the epidermal barrier integrity.
    
 
 0.559
APP
Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]
    
 0.546
SPINK2
Kazal-like domain-containing protein.
    
 0.544
CTRB2
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
0.543
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.