STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCSK7Proprotein convertase subtilisin/kexin type 7. (786 aa)    
Predicted Functional Partners:
LIPG
Lipase G, endothelial type.
    
 0.740
BSND
Barttin CLCNK type accessory beta subunit.
   
  
 0.725
USP24
Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family.
      
 0.677
C13H2orf40
Augurin.
      
 0.590
PDGFA
Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family.
     
 0.553
GPIHBP1
Uncharacterized protein.
     
 0.533
PCSK9
Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...]
      
 0.514
ANGPTL8
Angiopoietin like 8.
      
 0.503
MBTPS1
Membrane bound transcription factor peptidase, site 1.
      
 0.499
ANGPTL3
Angiopoietin like 3.
   
 
 0.493
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.