STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)    
Predicted Functional Partners:
TRIP12
Thyroid hormone receptor interactor 12.
   
  
0.855
UBR3
E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
   
  
 0.807
UBR2
E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
   
  
 0.652
UBA3
Ubiquitin like modifier activating enzyme 3.
     
 0.626
USP34
Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family.
   
    0.590
UBR4
Ubiquitin protein ligase E3 component n-recognin 4.
   
  
 0.589
APC2
APC regulator of WNT signaling pathway 2.
  
 
 0.536
GRM4
Glutamate metabotropic receptor 4.
      
 0.504
BIRC6
Baculoviral IAP repeat containing 6.
   
 
 0.501
SAT1
Spermidine/spermine N1-acetyltransferase 1.
      
 0.501
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.