SIX4 protein (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SIX4

SIX homeobox 4. (772 aa)

Predicted Functional Partners:

EYA2

0.754

EYA1

0.702

EYA3

0.683

EYA4

0.631

YAP1

0.569

LRRC17

0.555

PAX8

0.514

WNT4

0.465

PAX2

0.465

PRRX2

0.410

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EYA1	EYA2	ENSMNEP00000003899	ENSMNEP00000030852	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.484
EYA1	EYA3	ENSMNEP00000003899	ENSMNEP00000012507	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.491
EYA1	EYA4	ENSMNEP00000003899	ENSMNEP00000045976	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.504
EYA1	PAX2	ENSMNEP00000003899	ENSMNEP00000045509	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Paired box 2.	0.501
EYA1	SIX4	ENSMNEP00000003899	ENSMNEP00000000596	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 4.	0.702
EYA2	EYA1	ENSMNEP00000030852	ENSMNEP00000003899	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.484
EYA2	EYA3	ENSMNEP00000030852	ENSMNEP00000012507	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.569
EYA2	EYA4	ENSMNEP00000030852	ENSMNEP00000045976	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.487
EYA2	SIX4	ENSMNEP00000030852	ENSMNEP00000000596	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 4.	0.754
EYA3	EYA1	ENSMNEP00000012507	ENSMNEP00000003899	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.491
EYA3	EYA2	ENSMNEP00000012507	ENSMNEP00000030852	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.569
EYA3	EYA4	ENSMNEP00000012507	ENSMNEP00000045976	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.488
EYA3	SIX4	ENSMNEP00000012507	ENSMNEP00000000596	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 4.	0.683
EYA4	EYA1	ENSMNEP00000045976	ENSMNEP00000003899	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.504
EYA4	EYA2	ENSMNEP00000045976	ENSMNEP00000030852	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.487
EYA4	EYA3	ENSMNEP00000045976	ENSMNEP00000012507	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.488
EYA4	SIX4	ENSMNEP00000045976	ENSMNEP00000000596	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 4.	0.631
LRRC17	SIX4	ENSMNEP00000018192	ENSMNEP00000000596	Leucine rich repeat containing 17.	SIX homeobox 4.	0.555
PAX2	EYA1	ENSMNEP00000045509	ENSMNEP00000003899	Paired box 2.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.501
PAX2	SIX4	ENSMNEP00000045509	ENSMNEP00000000596	Paired box 2.	SIX homeobox 4.	0.465