DYRK2 protein (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

DYRK2

Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)

Predicted Functional Partners:

DCAF7

0.743

DCAF1

0.716

ATM

0.621

STYX

0.565

DDB1

0.532

MDM2

0.523

RNF11

0.503

UBR5

0.502

PIN1

0.472

PLK2

0.428

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	DYRK2	ENSMNEP00000001150	ENSMNEP00000003576	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Dual specificity tyrosine phosphorylation regulated kinase 2.	0.621
ATM	MDM2	ENSMNEP00000001150	ENSMNEP00000036531	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.947
DCAF1	DDB1	ENSMNEP00000039320	ENSMNEP00000015252	DDB1 and CUL4 associated factor 1.	Damage specific DNA binding protein 1.	0.999
DCAF1	DYRK2	ENSMNEP00000039320	ENSMNEP00000003576	DDB1 and CUL4 associated factor 1.	Dual specificity tyrosine phosphorylation regulated kinase 2.	0.716
DCAF7	DDB1	ENSMNEP00000004871	ENSMNEP00000015252	DDB1 and CUL4 associated factor 7.	Damage specific DNA binding protein 1.	0.964
DCAF7	DYRK2	ENSMNEP00000004871	ENSMNEP00000003576	DDB1 and CUL4 associated factor 7.	Dual specificity tyrosine phosphorylation regulated kinase 2.	0.743
DDB1	DCAF1	ENSMNEP00000015252	ENSMNEP00000039320	Damage specific DNA binding protein 1.	DDB1 and CUL4 associated factor 1.	0.999
DDB1	DCAF7	ENSMNEP00000015252	ENSMNEP00000004871	Damage specific DNA binding protein 1.	DDB1 and CUL4 associated factor 7.	0.964
DDB1	DYRK2	ENSMNEP00000015252	ENSMNEP00000003576	Damage specific DNA binding protein 1.	Dual specificity tyrosine phosphorylation regulated kinase 2.	0.532
DDB1	MDM2	ENSMNEP00000015252	ENSMNEP00000036531	Damage specific DNA binding protein 1.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.521
DDB1	UBR5	ENSMNEP00000015252	ENSMNEP00000009787	Damage specific DNA binding protein 1.	Ubiquitin protein ligase E3 component n-recognin 5.	0.522
DYRK2	ATM	ENSMNEP00000003576	ENSMNEP00000001150	Dual specificity tyrosine phosphorylation regulated kinase 2.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.621
DYRK2	DCAF1	ENSMNEP00000003576	ENSMNEP00000039320	Dual specificity tyrosine phosphorylation regulated kinase 2.	DDB1 and CUL4 associated factor 1.	0.716
DYRK2	DCAF7	ENSMNEP00000003576	ENSMNEP00000004871	Dual specificity tyrosine phosphorylation regulated kinase 2.	DDB1 and CUL4 associated factor 7.	0.743
DYRK2	DDB1	ENSMNEP00000003576	ENSMNEP00000015252	Dual specificity tyrosine phosphorylation regulated kinase 2.	Damage specific DNA binding protein 1.	0.532
DYRK2	MDM2	ENSMNEP00000003576	ENSMNEP00000036531	Dual specificity tyrosine phosphorylation regulated kinase 2.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.523
DYRK2	PIN1	ENSMNEP00000003576	ENSMNEP00000022455	Dual specificity tyrosine phosphorylation regulated kinase 2.	Peptidyl-prolyl cis-trans isomerase.	0.472
DYRK2	PLK2	ENSMNEP00000003576	ENSMNEP00000006563	Dual specificity tyrosine phosphorylation regulated kinase 2.	Serine/threonine-protein kinase PLK.	0.428
DYRK2	RNF11	ENSMNEP00000003576	ENSMNEP00000043090	Dual specificity tyrosine phosphorylation regulated kinase 2.	Ring finger protein 11.	0.503
DYRK2	STYX	ENSMNEP00000003576	ENSMNEP00000026020	Dual specificity tyrosine phosphorylation regulated kinase 2.	Serine/threonine/tyrosine interacting protein.	0.565