STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRF1Perforin. (555 aa)    
Predicted Functional Partners:
GZMB
Granzyme B; Belongs to the peptidase S1 family.
   
 0.940
GNLY
Granulysin.
   
  
 0.937
GZMA
Granzyme A; Belongs to the peptidase S1 family.
   
 0.920
CD8A
CD8a molecule.
   
  
 0.896
FASLG
Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...]
   
 
 0.861
KLRD1
Killer cell lectin like receptor D1.
   
 
 0.859
NKG7
Natural killer cell granule protein 7.
   
  
 0.849
IL2RB
Interleukin 2 receptor subunit beta.
   
  
 0.845
CD247
CD247 molecule.
   
  
 0.801
CTSW
Cathepsin W; Belongs to the peptidase C1 family.
   
 
 0.728
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.