| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATM | DAXX | ENSMNEP00000001150 | ENSMNEP00000034588 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Death domain associated protein. | 0.467 |
| ATM | MDM2 | ENSMNEP00000001150 | ENSMNEP00000036531 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.947 |
| ATM | MDM4 | ENSMNEP00000001150 | ENSMNEP00000005994 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.811 |
| DAXX | ATM | ENSMNEP00000034588 | ENSMNEP00000001150 | Death domain associated protein. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.467 |
| DAXX | MDM2 | ENSMNEP00000034588 | ENSMNEP00000036531 | Death domain associated protein. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.952 |
| DAXX | MDM4 | ENSMNEP00000034588 | ENSMNEP00000005994 | Death domain associated protein. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.812 |
| DAXX | USP7 | ENSMNEP00000034588 | ENSMNEP00000035984 | Death domain associated protein. | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. | 0.966 |
| ENSMNEP00000001309 | ENSMNEP00000008415 | ENSMNEP00000001309 | ENSMNEP00000008415 | Uncharacterized protein; Belongs to the universal ribosomal protein uL5 family. | Ubiquitin-like domain-containing protein. | 0.946 |
| ENSMNEP00000001309 | MDM2 | ENSMNEP00000001309 | ENSMNEP00000036531 | Uncharacterized protein; Belongs to the universal ribosomal protein uL5 family. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.918 |
| ENSMNEP00000001309 | MDM4 | ENSMNEP00000001309 | ENSMNEP00000005994 | Uncharacterized protein; Belongs to the universal ribosomal protein uL5 family. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.786 |
| ENSMNEP00000001309 | UBA52 | ENSMNEP00000001309 | ENSMNEP00000017349 | Uncharacterized protein; Belongs to the universal ribosomal protein uL5 family. | Ubiquitin A-52 residue ribosomal protein fusion product 1. | 0.946 |
| ENSMNEP00000008415 | ENSMNEP00000001309 | ENSMNEP00000008415 | ENSMNEP00000001309 | Ubiquitin-like domain-containing protein. | Uncharacterized protein; Belongs to the universal ribosomal protein uL5 family. | 0.946 |
| ENSMNEP00000008415 | MDM2 | ENSMNEP00000008415 | ENSMNEP00000036531 | Ubiquitin-like domain-containing protein. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.733 |
| ENSMNEP00000008415 | MDM4 | ENSMNEP00000008415 | ENSMNEP00000005994 | Ubiquitin-like domain-containing protein. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.814 |
| ENSMNEP00000008415 | RPL11 | ENSMNEP00000008415 | ENSMNEP00000009792 | Ubiquitin-like domain-containing protein. | Ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. | 0.946 |
| ENSMNEP00000008415 | USP7 | ENSMNEP00000008415 | ENSMNEP00000035984 | Ubiquitin-like domain-containing protein. | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. | 0.885 |
| MDM2 | ATM | ENSMNEP00000036531 | ENSMNEP00000001150 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.947 |
| MDM2 | DAXX | ENSMNEP00000036531 | ENSMNEP00000034588 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Death domain associated protein. | 0.952 |
| MDM2 | ENSMNEP00000001309 | ENSMNEP00000036531 | ENSMNEP00000001309 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Uncharacterized protein; Belongs to the universal ribosomal protein uL5 family. | 0.918 |
| MDM2 | ENSMNEP00000008415 | ENSMNEP00000036531 | ENSMNEP00000008415 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | Ubiquitin-like domain-containing protein. | 0.733 |