STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (640 aa)    
Predicted Functional Partners:
FREM3
FRAS1 related extracellular matrix 3.
    
 0.754
FREM1
FRAS1 related extracellular matrix 1.
    
 0.754
MMP11
Matrix metallopeptidase 11.
    
 0.664
PROC
Protein C, inactivator of coagulation factors Va and VIIIa.
   
 
 0.628
TGFB1
Transforming growth factor beta; Belongs to the TGF-beta family.
    
 0.625
F2
Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.
     
 0.615
FBN1
Fibrillin 1.
   
 
 0.614
PDGFB
Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.
   
 
  0.584
COL25A1
Collagen type XXV alpha 1 chain.
    
 0.564
PDGFA
Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family.
     
 0.564
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.