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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NOTCH2Notch receptor 2. (2471 aa)    
Predicted Functional Partners:
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region.
    
 0.984
JAG1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.978
DLL1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
0.971
JAG2
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.971
DLL3
Delta like canonical Notch ligand 3.
     
0.961
MAML1
Mastermind like transcriptional coactivator 1.
   
 0.957
DLL4
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
0.952
DTX3L
Deltex E3 ubiquitin ligase 3L.
    
 0.951
NUMB
NUMB endocytic adaptor protein.
    
 0.947
DTX1
Deltex E3 ubiquitin ligase 1.
    
 0.943
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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