MBD4 protein (Macaca nemestrina) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MBD4

Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (559 aa)

Predicted Functional Partners:

TDG

0.819

MTA3

0.706

MTA2

0.706

MTA1

0.706

DNMT1

0.658

BLZF1

0.646

NYNRIN

0.631

MAGT1

0.597

ARID4B

0.595

ARID4A

0.595

Your Current Organism:

Macaca nemestrina

NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID4A	ARID4B	ENSMNEP00000028380	ENSMNEP00000003255	AT-rich interaction domain 4A.	AT-rich interaction domain 4B.	0.643
ARID4A	MBD4	ENSMNEP00000028380	ENSMNEP00000010731	AT-rich interaction domain 4A.	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.	0.595
ARID4A	MTA1	ENSMNEP00000028380	ENSMNEP00000045101	AT-rich interaction domain 4A.	Metastasis associated 1.	0.749
ARID4A	MTA2	ENSMNEP00000028380	ENSMNEP00000036701	AT-rich interaction domain 4A.	Metastasis associated 1 family member 2.	0.749
ARID4A	MTA3	ENSMNEP00000028380	ENSMNEP00000025552	AT-rich interaction domain 4A.	Metastasis associated 1 family member 3.	0.749
ARID4A	NYNRIN	ENSMNEP00000028380	ENSMNEP00000017870	AT-rich interaction domain 4A.	NYN domain and retroviral integrase containing.	0.725
ARID4B	ARID4A	ENSMNEP00000003255	ENSMNEP00000028380	AT-rich interaction domain 4B.	AT-rich interaction domain 4A.	0.643
ARID4B	MBD4	ENSMNEP00000003255	ENSMNEP00000010731	AT-rich interaction domain 4B.	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.	0.595
ARID4B	MTA1	ENSMNEP00000003255	ENSMNEP00000045101	AT-rich interaction domain 4B.	Metastasis associated 1.	0.773
ARID4B	MTA2	ENSMNEP00000003255	ENSMNEP00000036701	AT-rich interaction domain 4B.	Metastasis associated 1 family member 2.	0.757
ARID4B	MTA3	ENSMNEP00000003255	ENSMNEP00000025552	AT-rich interaction domain 4B.	Metastasis associated 1 family member 3.	0.757
ARID4B	NYNRIN	ENSMNEP00000003255	ENSMNEP00000017870	AT-rich interaction domain 4B.	NYN domain and retroviral integrase containing.	0.725
BLZF1	MBD4	ENSMNEP00000029317	ENSMNEP00000010731	Basic leucine zipper nuclear factor 1.	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.	0.646
DNMT1	MBD4	ENSMNEP00000009892	ENSMNEP00000010731	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.	0.658
DNMT1	MTA1	ENSMNEP00000009892	ENSMNEP00000045101	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Metastasis associated 1.	0.439
DNMT1	TDG	ENSMNEP00000009892	ENSMNEP00000034547	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Thymine DNA glycosylase.	0.505
MAGT1	MBD4	ENSMNEP00000031807	ENSMNEP00000010731	Magnesium transporter 1.	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.	0.597
MBD4	ARID4A	ENSMNEP00000010731	ENSMNEP00000028380	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.	AT-rich interaction domain 4A.	0.595
MBD4	ARID4B	ENSMNEP00000010731	ENSMNEP00000003255	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.	AT-rich interaction domain 4B.	0.595
MBD4	BLZF1	ENSMNEP00000010731	ENSMNEP00000029317	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.	Basic leucine zipper nuclear factor 1.	0.646

page 1 of 3

Server load: medium (56%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About