node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DHTKD1 | OGDH | ENSMNEP00000029709 | ENSMNEP00000029470 | Dehydrogenase E1 and transketolase domain containing 1. | Oxoglutarate dehydrogenase. | 0.605 |
DHTKD1 | OGDHL | ENSMNEP00000029709 | ENSMNEP00000032865 | Dehydrogenase E1 and transketolase domain containing 1. | Oxoglutarate dehydrogenase like. | 0.602 |
DHTKD1 | RNF8 | ENSMNEP00000029709 | ENSMNEP00000020843 | Dehydrogenase E1 and transketolase domain containing 1. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.878 |
ENSMNEP00000015473 | LOC105499496 | ENSMNEP00000015473 | ENSMNEP00000003212 | Uncharacterized protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.952 |
ENSMNEP00000015473 | MDC1 | ENSMNEP00000015473 | ENSMNEP00000044810 | Uncharacterized protein. | Mediator of DNA damage checkpoint 1. | 0.420 |
ENSMNEP00000015473 | RNF168 | ENSMNEP00000015473 | ENSMNEP00000009896 | Uncharacterized protein. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.502 |
ENSMNEP00000015473 | RNF8 | ENSMNEP00000015473 | ENSMNEP00000020843 | Uncharacterized protein. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.869 |
ENSMNEP00000015473 | TP53BP1 | ENSMNEP00000015473 | ENSMNEP00000031137 | Uncharacterized protein. | Tumor protein p53 binding protein 1. | 0.645 |
HERC2 | LOC105499496 | ENSMNEP00000025537 | ENSMNEP00000003212 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.403 |
HERC2 | MDC1 | ENSMNEP00000025537 | ENSMNEP00000044810 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. | Mediator of DNA damage checkpoint 1. | 0.467 |
HERC2 | RNF168 | ENSMNEP00000025537 | ENSMNEP00000009896 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.561 |
HERC2 | RNF8 | ENSMNEP00000025537 | ENSMNEP00000020843 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.851 |
HERC2 | TP53BP1 | ENSMNEP00000025537 | ENSMNEP00000031137 | HECT and RLD domain containing E3 ubiquitin protein ligase 2. | Tumor protein p53 binding protein 1. | 0.536 |
LOC105486897 | LOC105499496 | ENSMNEP00000034891 | ENSMNEP00000003212 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.916 |
LOC105486897 | MDC1 | ENSMNEP00000034891 | ENSMNEP00000044810 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Mediator of DNA damage checkpoint 1. | 0.489 |
LOC105486897 | RNF168 | ENSMNEP00000034891 | ENSMNEP00000009896 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.749 |
LOC105486897 | RNF8 | ENSMNEP00000034891 | ENSMNEP00000020843 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.851 |
LOC105486897 | TP53BP1 | ENSMNEP00000034891 | ENSMNEP00000031137 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Tumor protein p53 binding protein 1. | 0.663 |
LOC105499496 | ENSMNEP00000015473 | ENSMNEP00000003212 | ENSMNEP00000015473 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | Uncharacterized protein. | 0.952 |
LOC105499496 | HERC2 | ENSMNEP00000003212 | ENSMNEP00000025537 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | HECT and RLD domain containing E3 ubiquitin protein ligase 2. | 0.403 |