STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GRK6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (616 aa)    
Predicted Functional Partners:
CXCR4
C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.
    
 0.965
CCR5
C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).
    
  0.959
ARRB1
Arrestin beta 1.
   
 0.908
OPRM1
Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family.
    
  0.896
ARRB2
Arrestin beta 2.
   
 0.895
XCR1
X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.
   
  0.853
CX3CR1
C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family.
    
  0.852
CCR6
C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family.
    
  0.852
RHO
Rhodopsin.
   
 0.821
RCVRN
Recoverin.
   
 0.813
Your Current Organism:
Macaca nemestrina
NCBI taxonomy Id: 9545
Other names: M. nemestrina, pig-tailed macaque, pigtail macaque, pigtail monkey
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.