node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AADAT | AFMID | ENSMNEP00000003110 | ENSMNEP00000010567 | Aminoadipate aminotransferase. | Arylformamidase. | 0.945 |
AADAT | AGXT | ENSMNEP00000003110 | ENSMNEP00000031651 | Aminoadipate aminotransferase. | Serine--pyruvate aminotransferase. | 0.459 |
AADAT | HAAO | ENSMNEP00000003110 | ENSMNEP00000025420 | Aminoadipate aminotransferase. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. | 0.511 |
AADAT | KMO | ENSMNEP00000003110 | ENSMNEP00000041264 | Aminoadipate aminotransferase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.946 |
AADAT | KYAT1 | ENSMNEP00000003110 | ENSMNEP00000014360 | Aminoadipate aminotransferase. | Aminotran_1_2 domain-containing protein. | 0.928 |
AADAT | KYAT3 | ENSMNEP00000003110 | ENSMNEP00000003535 | Aminoadipate aminotransferase. | Kynurenine aminotransferase 3. | 0.947 |
AADAT | KYNU | ENSMNEP00000003110 | ENSMNEP00000007454 | Aminoadipate aminotransferase. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | 0.958 |
AFMID | AADAT | ENSMNEP00000010567 | ENSMNEP00000003110 | Arylformamidase. | Aminoadipate aminotransferase. | 0.945 |
AFMID | HAAO | ENSMNEP00000010567 | ENSMNEP00000025420 | Arylformamidase. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. | 0.528 |
AFMID | KMO | ENSMNEP00000010567 | ENSMNEP00000041264 | Arylformamidase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.951 |
AFMID | KYAT1 | ENSMNEP00000010567 | ENSMNEP00000014360 | Arylformamidase. | Aminotran_1_2 domain-containing protein. | 0.910 |
AFMID | KYAT3 | ENSMNEP00000010567 | ENSMNEP00000003535 | Arylformamidase. | Kynurenine aminotransferase 3. | 0.944 |
AFMID | KYNU | ENSMNEP00000010567 | ENSMNEP00000007454 | Arylformamidase. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | 0.967 |
AFMID | PEMT | ENSMNEP00000010567 | ENSMNEP00000009168 | Arylformamidase. | Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. | 0.525 |
AGXT | AADAT | ENSMNEP00000031651 | ENSMNEP00000003110 | Serine--pyruvate aminotransferase. | Aminoadipate aminotransferase. | 0.459 |
AGXT | KMO | ENSMNEP00000031651 | ENSMNEP00000041264 | Serine--pyruvate aminotransferase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.883 |
AGXT | KYAT1 | ENSMNEP00000031651 | ENSMNEP00000014360 | Serine--pyruvate aminotransferase. | Aminotran_1_2 domain-containing protein. | 0.561 |
AGXT | KYAT3 | ENSMNEP00000031651 | ENSMNEP00000003535 | Serine--pyruvate aminotransferase. | Kynurenine aminotransferase 3. | 0.561 |
AGXT | KYNU | ENSMNEP00000031651 | ENSMNEP00000007454 | Serine--pyruvate aminotransferase. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | 0.551 |
CYB5R4 | KMO | ENSMNEP00000030813 | ENSMNEP00000041264 | Cytochrome b5 reductase 4. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.887 |