glnE protein (Burkholderia cenocepacia) - STRING interaction network

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glnE

Glutamate-ammonia ligase adenylyltransferase family protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds th [...] (933 aa)

Predicted Functional Partners:

glnD

0.830

glnA

0.754

DM40_1433

0.610

DM40_1121

0.563

acpS

0.560

hrpA

0.530

DM40_400

0.522

argA

0.511

glnB_1

0.487

DM40_1432

0.483

Your Current Organism:

Burkholderia cenocepacia

NCBI taxonomy Id: 95486
Other names: ATCC BAA-245, ATCC:BAA:245, B. cenocepacia, Burkholderia cenocepacia Vandamme et al. 2003, Burkholderia cepacia genomovar III, Burkholderia cepacia genomovar IIIb, CCM 4899, CCUG 48434, DSM 16553, LMG 16656, LMG:16656, NCTC 13227

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DM40_1121	DM40_1432	DM40_1121	DM40_1432	Glutamine amidotransferases class-II family protein.	Carbon-nitrogen hydrolase family protein.	0.865
DM40_1121	argA	DM40_1121	DM40_2796	Glutamine amidotransferases class-II family protein.	N-Ac-Glu-synth: amino-acid N-acetyltransferase; Belongs to the acetyltransferase family. ArgA subfamily.	0.651
DM40_1121	glnA	DM40_1121	DM40_2789	Glutamine amidotransferases class-II family protein.	glnA: glutamine synthetase, type I.	0.987
DM40_1121	glnB_1	DM40_1121	DM40_468	Glutamine amidotransferases class-II family protein.	Nitrogen regulatory P-II family protein; Belongs to the P(II) protein family.	0.578
DM40_1121	glnD	DM40_1121	DM40_2658	Glutamine amidotransferases class-II family protein.	protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.	0.585
DM40_1121	glnE	DM40_1121	DM40_1434	Glutamine amidotransferases class-II family protein.	Glutamate-ammonia ligase adenylyltransferase family protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds th [...]	0.563
DM40_1432	DM40_1121	DM40_1432	DM40_1121	Carbon-nitrogen hydrolase family protein.	Glutamine amidotransferases class-II family protein.	0.865
DM40_1432	DM40_1433	DM40_1432	DM40_1433	Carbon-nitrogen hydrolase family protein.	Hypothetical protein.	0.721
DM40_1432	glnA	DM40_1432	DM40_2789	Carbon-nitrogen hydrolase family protein.	glnA: glutamine synthetase, type I.	0.401
DM40_1432	glnE	DM40_1432	DM40_1434	Carbon-nitrogen hydrolase family protein.	Glutamate-ammonia ligase adenylyltransferase family protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds th [...]	0.483
DM40_1433	DM40_1432	DM40_1433	DM40_1432	Hypothetical protein.	Carbon-nitrogen hydrolase family protein.	0.721
DM40_1433	DM40_400	DM40_1433	DM40_400	Hypothetical protein.	Tetratricopeptide repeat family protein.	0.540
DM40_1433	glnE	DM40_1433	DM40_1434	Hypothetical protein.	Glutamate-ammonia ligase adenylyltransferase family protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds th [...]	0.610
DM40_400	DM40_1433	DM40_400	DM40_1433	Tetratricopeptide repeat family protein.	Hypothetical protein.	0.540
DM40_400	glnE	DM40_400	DM40_1434	Tetratricopeptide repeat family protein.	Glutamate-ammonia ligase adenylyltransferase family protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds th [...]	0.522
acpS	glnE	DM40_1800	DM40_1434	Holo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family.	Glutamate-ammonia ligase adenylyltransferase family protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds th [...]	0.560
argA	DM40_1121	DM40_2796	DM40_1121	N-Ac-Glu-synth: amino-acid N-acetyltransferase; Belongs to the acetyltransferase family. ArgA subfamily.	Glutamine amidotransferases class-II family protein.	0.651
argA	glnA	DM40_2796	DM40_2789	N-Ac-Glu-synth: amino-acid N-acetyltransferase; Belongs to the acetyltransferase family. ArgA subfamily.	glnA: glutamine synthetase, type I.	0.469
argA	glnB_1	DM40_2796	DM40_468	N-Ac-Glu-synth: amino-acid N-acetyltransferase; Belongs to the acetyltransferase family. ArgA subfamily.	Nitrogen regulatory P-II family protein; Belongs to the P(II) protein family.	0.923
argA	glnD	DM40_2796	DM40_2658	N-Ac-Glu-synth: amino-acid N-acetyltransferase; Belongs to the acetyltransferase family. ArgA subfamily.	protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.	0.408

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