| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DM40_1296 | apt | DM40_1296 | DM40_385 | Phosphoribosyl transferase domain protein. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.976 |
| DM40_1296 | gmk | DM40_1296 | DM40_1654 | Phosphoribosyl transferase domain protein. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.971 |
| DM40_1296 | guaA | DM40_1296 | DM40_2626 | Phosphoribosyl transferase domain protein. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.976 |
| DM40_1296 | guaB | DM40_1296 | DM40_2628 | Phosphoribosyl transferase domain protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.974 |
| DM40_1296 | purL | DM40_1296 | DM40_2514 | Phosphoribosyl transferase domain protein. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.530 |
| DM40_1296 | pyrG | DM40_1296 | DM40_2749 | Phosphoribosyl transferase domain protein. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.437 |
| DM40_1296 | rdgB | DM40_1296 | DM40_1651 | Phosphoribosyl transferase domain protein. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.951 |
| apt | DM40_1296 | DM40_385 | DM40_1296 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosyl transferase domain protein. | 0.976 |
| apt | gmk | DM40_385 | DM40_1654 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.984 |
| apt | guaA | DM40_385 | DM40_2626 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.998 |
| apt | guaB | DM40_385 | DM40_2628 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.909 |
| apt | purL | DM40_385 | DM40_2514 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.887 |
| apt | pyrG | DM40_385 | DM40_2749 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.674 |
| apt | rdgB | DM40_385 | DM40_1651 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.647 |
| argS | gmk | DM40_519 | DM40_1654 | argS: arginine--tRNA ligase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.628 |
| argS | guaA | DM40_519 | DM40_2626 | argS: arginine--tRNA ligase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.976 |
| argS | guaB | DM40_519 | DM40_2628 | argS: arginine--tRNA ligase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.460 |
| argS | lysS | DM40_519 | DM40_2758 | argS: arginine--tRNA ligase. | lysS_bact: lysine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.969 |
| argS | purL | DM40_519 | DM40_2514 | argS: arginine--tRNA ligase. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.714 |
| argS | pyrG | DM40_519 | DM40_2749 | argS: arginine--tRNA ligase. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.899 |