| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DM40_1121 | DM40_2788 | DM40_1121 | DM40_2788 | Glutamine amidotransferases class-II family protein. | Sensory box protein. | 0.415 |
| DM40_1121 | glnB | DM40_1121 | DM40_47 | Glutamine amidotransferases class-II family protein. | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | 0.679 |
| DM40_1121 | glnB_1 | DM40_1121 | DM40_468 | Glutamine amidotransferases class-II family protein. | Nitrogen regulatory P-II family protein; Belongs to the P(II) protein family. | 0.635 |
| DM40_1121 | glnD | DM40_1121 | DM40_2658 | Glutamine amidotransferases class-II family protein. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.633 |
| DM40_1121 | glnE | DM40_1121 | DM40_1434 | Glutamine amidotransferases class-II family protein. | Glutamate-ammonia ligase adenylyltransferase family protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds th [...] | 0.612 |
| DM40_1121 | rpsB | DM40_1121 | DM40_2656 | Glutamine amidotransferases class-II family protein. | rpsB_bact: ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. | 0.624 |
| DM40_2788 | DM40_1121 | DM40_2788 | DM40_1121 | Sensory box protein. | Glutamine amidotransferases class-II family protein. | 0.415 |
| DM40_2788 | glnB | DM40_2788 | DM40_47 | Sensory box protein. | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | 0.980 |
| DM40_2788 | glnB_1 | DM40_2788 | DM40_468 | Sensory box protein. | Nitrogen regulatory P-II family protein; Belongs to the P(II) protein family. | 0.811 |
| DM40_2788 | glnD | DM40_2788 | DM40_2658 | Sensory box protein. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.639 |
| DM40_2788 | glnE | DM40_2788 | DM40_1434 | Sensory box protein. | Glutamate-ammonia ligase adenylyltransferase family protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds th [...] | 0.458 |
| cbiA | glnD | DM40_2283 | DM40_2658 | cobB/CobQ-like glutamine amidotransferase domain protein; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.524 |
| dsbB | glnD | DM40_1682 | DM40_2658 | Disulfide bond formation DsbB family protein; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.556 |
| glnB | DM40_1121 | DM40_47 | DM40_1121 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | Glutamine amidotransferases class-II family protein. | 0.679 |
| glnB | DM40_2788 | DM40_47 | DM40_2788 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | Sensory box protein. | 0.980 |
| glnB | glnD | DM40_47 | DM40_2658 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.985 |
| glnB | glnE | DM40_47 | DM40_1434 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | Glutamate-ammonia ligase adenylyltransferase family protein; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds th [...] | 0.549 |
| glnB_1 | DM40_1121 | DM40_468 | DM40_1121 | Nitrogen regulatory P-II family protein; Belongs to the P(II) protein family. | Glutamine amidotransferases class-II family protein. | 0.635 |
| glnB_1 | DM40_2788 | DM40_468 | DM40_2788 | Nitrogen regulatory P-II family protein; Belongs to the P(II) protein family. | Sensory box protein. | 0.811 |
| glnB_1 | glnD | DM40_468 | DM40_2658 | Nitrogen regulatory P-II family protein; Belongs to the P(II) protein family. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.864 |
