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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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DM40_2839Hydrolyase, tartrate alpha subunit/fumarate, Fe-S type domain protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa)    
Predicted Functional Partners:
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 
 0.996
sdhA
sdhA_forward: succinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
  
 
 0.994
sdhB
dhsB: succinate dehydrogenase and fumarate reductase iron-sulfur family protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 
 0.989
sdhB-2
dhsB: succinate dehydrogenase and fumarate reductase iron-sulfur family protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 
 0.989
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
   
  
 0.987
sdhD
Succ_dehyd_anc: succinate dehydrogenase, hydrophobic membrane anchor protein.
  
 
 0.985
sdhC
succ_dehyd_cytB: succinate dehydrogenase, cytochrome b556 subunit.
  
 
 0.979
sdhC-2
succ_dehyd_cytB: succinate dehydrogenase, cytochrome b556 subunit.
  
 
 0.979
fumC
Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 
 0.976
DM40_170
merR regulatory family protein.
  
 
 0.971
Your Current Organism:
Burkholderia cenocepacia
NCBI taxonomy Id: 95486
Other names: ATCC BAA-245, ATCC:BAA:245, B. cenocepacia, Burkholderia cenocepacia Vandamme et al. 2003, Burkholderia cepacia genomovar III, Burkholderia cepacia genomovar IIIb, CCM 4899, CCUG 48434, DSM 16553, LMG 16656, LMG:16656, NCTC 13227
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