| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DM40_4171 | ada | DM40_4171 | DM40_747 | RNA polymerase sigma factor, sigma-70 family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | Bifunctional transcriptional activator/DNA repair enzyme Ada; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family. | 0.929 |
| DM40_4171 | dnaG | DM40_4171 | DM40_3902 | RNA polymerase sigma factor, sigma-70 family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.705 |
| DM40_4171 | infC | DM40_4171 | DM40_2105 | RNA polymerase sigma factor, sigma-70 family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | 0.691 |
| DM40_4171 | recA | DM40_4171 | DM40_278 | RNA polymerase sigma factor, sigma-70 family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.752 |
| DM40_4171 | rpoA | DM40_4171 | DM40_1093 | RNA polymerase sigma factor, sigma-70 family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.956 |
| DM40_4171 | rpoB | DM40_4171 | DM40_1059 | RNA polymerase sigma factor, sigma-70 family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.958 |
| DM40_4171 | rpoC | DM40_4171 | DM40_1060 | RNA polymerase sigma factor, sigma-70 family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.941 |
| DM40_4171 | rpoZ | DM40_4171 | DM40_1655 | RNA polymerase sigma factor, sigma-70 family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.893 |
| DM40_4171 | secA | DM40_4171 | DM40_1275 | RNA polymerase sigma factor, sigma-70 family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | Preprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. | 0.787 |
| DM40_4171 | secY | DM40_4171 | DM40_1087 | RNA polymerase sigma factor, sigma-70 family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.714 |
| ada | DM40_4171 | DM40_747 | DM40_4171 | Bifunctional transcriptional activator/DNA repair enzyme Ada; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family. | RNA polymerase sigma factor, sigma-70 family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.929 |
| ada | recA | DM40_747 | DM40_278 | Bifunctional transcriptional activator/DNA repair enzyme Ada; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family. | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.600 |
| dnaG | DM40_4171 | DM40_3902 | DM40_4171 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | RNA polymerase sigma factor, sigma-70 family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.705 |
| dnaG | infC | DM40_3902 | DM40_2105 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | 0.536 |
| dnaG | recA | DM40_3902 | DM40_278 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.615 |
| dnaG | rpoA | DM40_3902 | DM40_1093 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.710 |
| dnaG | rpoB | DM40_3902 | DM40_1059 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.707 |
| dnaG | rpoC | DM40_3902 | DM40_1060 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.591 |
| dnaG | secA | DM40_3902 | DM40_1275 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | Preprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. | 0.812 |
| infC | DM40_4171 | DM40_2105 | DM40_4171 | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | RNA polymerase sigma factor, sigma-70 family protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.691 |
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